3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzene-1-sulfonyl chloride

Base Information

Chemical Name:3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzene-1-sulfonyl chloride
CAS No.:1418274-38-0
Molecular Formula:C₂₉H₂₃Cl₄NO₅S
Molecular Weight:639.383
Hs Code.:

Synonyms:3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzene-1-sulfonyl chloride

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Chemical Property of 3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzene-1-sulfonyl chloride

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Technology Process of 3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzene-1-sulfonyl chloride

There total 8 articles about 3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzene-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418274-37-9
3-(3-(Benzylthio)phenyl)-1-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclobutanol

: 1418274-38-0
3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzene-1-sulfonyl chloride

Guidance literature:: With 1,3-dichloro-5,5-dimethylhydantoin; acetic acid; In water; acetonitrile; at 0 - 5 ℃; for 2h;

Reference yield:

: 946426-89-7
4-(hydroxymethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole

: 1418274-38-0
3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzene-1-sulfonyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 21 h / 20 °C / Cooling with ice

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

2.2: -78 - 20 °C

3.1: potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 4 h / 115 °C / Inert atmosphere

4.1: acetic acid; 1,3-dichloro-5,5-dimethylhydantoin / water; acetonitrile / 2 h / 0 - 5 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; 1,3-dichloro-5,5-dimethylhydantoin; di-isopropyl azodicarboxylate; potassium carbonate; acetic acid; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; hexane; water; toluene; acetonitrile;

Reference yield:

: 2039-86-3,25584-47-8
3-bromostyrene

: 1418274-38-0
3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzene-1-sulfonyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoromethylsulfonic anhydride / 1,2-dichloro-ethane / 1 h / 0 °C

1.2: Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

2.2: -78 - 20 °C

3.1: potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 4 h / 115 °C / Inert atmosphere

4.1: acetic acid; 1,3-dichloro-5,5-dimethylhydantoin / water; acetonitrile / 2 h / 0 - 5 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; 1,3-dichloro-5,5-dimethylhydantoin; trifluoromethylsulfonic anhydride; potassium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; hexane; water; 1,2-dichloro-ethane; toluene; acetonitrile;