Methyl (2R,4R)-2-phenyl-3-<2-(prop-2-ynyloxybenzoyl)>hiazolidine-4-carboxylate

Base Information

• Chemical Name: Methyl (2R,4R)-2-phenyl-3-<2-(prop-2-ynyloxybenzoyl)>hiazolidine-4-carboxylate
• CAS No.: 230955-92-7
• Molecular Formula: C₂₁H₁₉NO₄S
• Molecular Weight: 381.452
• Mol file: 230955-92-7.mol

Synonyms:Methyl (2R,4R)-2-phenyl-3-<2-(prop-2-ynyloxybenzoyl)>hiazolidine-4-carboxylate

Chemical Property of Methyl (2R,4R)-2-phenyl-3-<2-(prop-2-ynyloxybenzoyl)>hiazolidine-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl (2R,4R)-2-phenyl-3-<2-(prop-2-ynyloxybenzoyl)>hiazolidine-4-carboxylate

There total 4 articles about Methyl (2R,4R)-2-phenyl-3-<2-(prop-2-ynyloxybenzoyl)>hiazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

methyl (4R)-2-phenylthiazolidine-4-carboxylate (198991-76-3,69739-20-4) + 2-Prop-2-ynyloxybenzoic acid chloride (65211-53-2) → Methyl (2R,4R)-2-phenyl-3-<2-(prop-2-ynyloxybenzoyl)>hiazolidine-4-carboxylate (230955-92-7)

Guidance literature:

With potassium carbonate; In dichloromethane; for 18h; Ambient temperature;

Reference yield:

methyl 2-(prop-2-yn-1-yloxy)benzoate (59155-84-9) → Methyl (2R,4R)-2-phenyl-3-<2-(prop-2-ynyloxybenzoyl)>hiazolidine-4-carboxylate (230955-92-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / H₂O, KOH / ethanol / 25 h / Ambient temperature

2: SOCl₂ / 0.5 h / Heating

3: 49 percent / K₂CO₃ / CH₂Cl₂ / 18 h / Ambient temperature

With potassium hydroxide; thionyl chloride; water; potassium carbonate; In ethanol; dichloromethane;

Reference yield:

2-(prop-2-yn-1-yloxy)benzoic acid (55582-31-5) → Methyl (2R,4R)-2-phenyl-3-<2-(prop-2-ynyloxybenzoyl)>hiazolidine-4-carboxylate (230955-92-7)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 0.5 h / Heating

2: 49 percent / K₂CO₃ / CH₂Cl₂ / 18 h / Ambient temperature

With thionyl chloride; potassium carbonate; In dichloromethane;

upstream raw materials:

methyl (4R)-2-phenylthiazolidine-4-carboxylate

2-Prop-2-ynyloxybenzoic acid chloride

methyl 2-(prop-2-yn-1-yloxy)benzoate

2-(prop-2-yn-1-yloxy)benzoic acid

Downstream raw materials:

(2R,4R)-2-Phenyl-3-<2-(prop-2-ynyloxybenzoyl)>thiazolidine-4-carboxylic acid