N-(2,4-difluorophenyl)-5-[8-(2-furanyl)-1,5-naphthyridin-2-yl]-3-pyridinesulfonamide

Base Information

Chemical Name:N-(2,4-difluorophenyl)-5-[8-(2-furanyl)-1,5-naphthyridin-2-yl]-3-pyridinesulfonamide
CAS No.:1092565-23-5
Molecular Formula:C₂₃H₁₄F₂N₄O₃S
Molecular Weight:464.452
Hs Code.:

Synonyms:N-(2,4-difluorophenyl)-5-[8-(2-furanyl)-1,5-naphthyridin-2-yl]-3-pyridinesulfonamide

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Chemical Property of N-(2,4-difluorophenyl)-5-[8-(2-furanyl)-1,5-naphthyridin-2-yl]-3-pyridinesulfonamide

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Technology Process of N-(2,4-difluorophenyl)-5-[8-(2-furanyl)-1,5-naphthyridin-2-yl]-3-pyridinesulfonamide

There total 7 articles about N-(2,4-difluorophenyl)-5-[8-(2-furanyl)-1,5-naphthyridin-2-yl]-3-pyridinesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1092565-24-6
5-(8-chloro-1,5-naphthyridin-2-yl)-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

: 118486-94-5
2-(tributylstannyl)furan

: 1092565-23-5
N-(2,4-difluorophenyl)-5-[8-(2-furanyl)-1,5-naphthyridin-2-yl]-3-pyridinesulfonamide

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 18h; Sealed tube;

Reference yield:

: 249889-68-7
8-chloro-2-methoxy-1,5-naphthyridine

: 1092565-23-5
N-(2,4-difluorophenyl)-5-[8-(2-furanyl)-1,5-naphthyridin-2-yl]-3-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane / 20 h / 100 °C / Sealed tube

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3: water; sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.5 h / 100 °C / Sealed tube

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / 100 °C / Sealed tube

With hydrogenchloride; water; sodium hydrogencarbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 8-chloro-1,5-naphthyridin-2-ol dihydrochloride

: 1092565-23-5
N-(2,4-difluorophenyl)-5-[8-(2-furanyl)-1,5-naphthyridin-2-yl]-3-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: water; sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.5 h / 100 °C / Sealed tube

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / 100 °C / Sealed tube

With water; sodium hydrogencarbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; N,N-dimethyl-formamide;