8-CHLORO-2-METHOXY-1,5-NAPHTHYRIDINE

Base Information

• Chemical Name: 8-CHLORO-2-METHOXY-1,5-NAPHTHYRIDINE
• CAS No.: 249889-68-7
• Molecular Formula: C9H7 Cl N2 O
• Molecular Weight: 194.62
• Hs Code.: 2933990090
• Mol file: 249889-68-7.mol

Synonyms:4-Chloro-6-methoxy-1,5-naphthyridine;8-Chloro-2-(methyloxy)-1,5-naphthyridine; 8-Chloro-2-methoxy-1,5-naphthyridine

Chemical Property of 8-CHLORO-2-METHOXY-1,5-NAPHTHYRIDINE

Chemical Property:

• Boiling Point: 287.4±35.0 °C(Predicted)
• PKA: 1.39±0.10(Predicted)
• PSA: 35.01000
• Density: 1.333±0.06 g/cm3(Predicted)
• LogP: 2.29180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

8-Chloro-2-methoxy-1,5-naphthyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-CHLORO-2-METHOXY-1,5-NAPHTHYRIDINE

There total 6 articles about 8-CHLORO-2-METHOXY-1,5-NAPHTHYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methoxy-1,5-naphthyridin-4(1H)-one (23443-25-6,443955-22-4) → 8-chloro-2-methoxy-1,5-naphthyridine (249889-68-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; at 100 ℃; for 1h;

Reference yield:

6-methoxy-1,5-naphthyridin-4-ol (23443-25-6) → 8-chloro-2-methoxy-1,5-naphthyridine (249889-68-7)

Guidance literature:

With trichlorophosphate; at 20 ℃; for 3h;

Reference yield:

6-methoxy-4-oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic acid (53241-85-3) → 8-chloro-2-methoxy-1,5-naphthyridine (249889-68-7)

Guidance literature:

With trichlorophosphate; In quinoline;

upstream raw materials:

6-methoxy-1,5-naphthyridin-4-ol

6-methoxy-4-oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic acid

6-methoxy-1,5-naphthyridin-4(1H)-one

6-methoxy-pyridin-3-ylamine

Downstream raw materials:

2-[2-methoxy-4-(6-methoxy-1,5-naphthyridin-4-yloxy)phenyl]acetic acid

N-(2,4-difluorophenyl)-5-[8-(4-methyl-1-piperazinyl)-1,5-naphthyridin-2-yl]-3-pyridinesulfonamide

N-[5-(8-{4-[(dimethylamino)methyl]phenyl}-1,5-naphthyridin-2-yl)-3-pyridinyl]benzenesulfonamide

N-{5-[8-(4-hydroxy-1-piperidinyl)-1,5-naphthyridin-2-yl]-3-pyridinyl}benzenesulfonamide