(6-Morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-carbamic acid methyl ester

Base Information

Chemical Name:(6-Morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-carbamic acid methyl ester
CAS No.:342417-07-6
Molecular Formula:C₁₈H₂₁N₃O₃
Molecular Weight:327.383
Hs Code.:
DSSTox Substance ID:DTXSID201134852

Synonyms:SCHEMBL7111358;YCMZOWWCFKXMSI-UHFFFAOYSA-N;DTXSID201134852;(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-carbamic acid methyl ester;342417-07-6;Carbamic acid, [4-(2-methylphenyl)-6-(4-morpholinyl)-3-pyridinyl]-, methyl ester

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Chemical Property of (6-Morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-carbamic acid methyl ester

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:327.15829154
Heavy Atom Count:24
Complexity:414

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=CC=C1C2=CC(=NC=C2NC(=O)OC)N3CCOCC3

Technology Process of (6-Morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-carbamic acid methyl ester

There total 19 articles about (6-Morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 342417-06-5
4-(2-methylphenyl)-6-(4-morpholinyl)-3-pyridinecarboxamide

: 124-41-4
sodium methylate

: 342417-07-6
[6-(morpholin-4-yl)-4-(o-tolyl)pyridin-3-yl]carbamic acid methyl ester

Guidance literature:: With N-Bromosuccinimide; In methanol; dichloromethane; at -5 ℃; for 7h;
DOI:10.1021/jo0523666

Reference yield:

: 342417-04-3
N-tert-butyl-6-chloro-4-(o-tolyl)nicotinamide

: 342417-07-6
[6-(morpholin-4-yl)-4-(o-tolyl)pyridin-3-yl]carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 58.7 g / 5 h / 100 °C

2: 95 percent / MeSO₃H / 5 h / 100 °C

3: 86 percent / N-bromosuccinimide / CH₂Cl₂; methanol / 7 h / -5 °C

With N-Bromosuccinimide; methanesulfonic acid; In methanol; dichloromethane; 3: Hoffmann rearrangement;
DOI:10.1021/jo0523666

Reference yield:

: 342417-05-4
N-tert-butyl-6-(morpholin-4-yl)-4-(o-tolyl)nicotinamide

: 342417-07-6
[6-(morpholin-4-yl)-4-(o-tolyl)pyridin-3-yl]carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / MeSO₃H / 5 h / 100 °C

2: 86 percent / N-bromosuccinimide / CH₂Cl₂; methanol / 7 h / -5 °C

With N-Bromosuccinimide; methanesulfonic acid; In methanol; dichloromethane; 2: Hoffmann rearrangement;
DOI:10.1021/jo0523666