N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-cyano-2-fluorobenzamide

Base Information

Chemical Name:N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-cyano-2-fluorobenzamide
CAS No.:1436426-37-7
Molecular Formula:C₂₁H₁₉ClF₄N₄O
Molecular Weight:454.855
Hs Code.:

Synonyms:N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-cyano-2-fluorobenzamide

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Chemical Property of N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-cyano-2-fluorobenzamide

Chemical Property:

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Technology Process of N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-cyano-2-fluorobenzamide

There total 6 articles about N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-cyano-2-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 175596-02-8
4-cyano-2-fluoro benzoyl chloride

: 1436426-21-9
4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline

: 1436426-37-7
N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-cyano-2-fluorobenzamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1436426-21-9
4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline

: 164149-28-4
4-cyano-2-fluorobenzoic acid

: 1436426-37-7
N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-cyano-2-fluorobenzamide

Guidance literature:: 4-cyano-2-fluorobenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 2h;

4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 1436426-37-7
N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-cyano-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: isopropyl alcohol / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol / Reflux

3: ethanol; tin(ll) chloride / 1 h / 80 °C / Cooling with ice

4: triethylamine / dichloromethane / 1 h / 20 °C

With ethanol; triethylamine; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;