diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 2-{2-[4-(4-dimethylamino-phenylazo)-benzoylamino]-ethoxy}-ethyl ester

Base Information

• Chemical Name: diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 2-{2-[4-(4-dimethylamino-phenylazo)-benzoylamino]-ethoxy}-ethyl ester
• CAS No.: 247059-51-4
• Molecular Formula: C₂₈H₄₁N₆O₄P
• Molecular Weight: 556.645
• Mol file: 247059-51-4.mol

Synonyms:diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 2-{2-[4-(4-dimethylamino-phenylazo)-benzoylamino]-ethoxy}-ethyl ester

Chemical Property of diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 2-{2-[4-(4-dimethylamino-phenylazo)-benzoylamino]-ethoxy}-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 2-{2-[4-(4-dimethylamino-phenylazo)-benzoylamino]-ethoxy}-ethyl ester

There total 2 articles about diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 2-{2-[4-(4-dimethylamino-phenylazo)-benzoylamino]-ethoxy}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 4-(4-dimethylamino-phenylazo)-N-[2-(2-hydroxy-ethoxy)-ethyl]-benzamide → diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 2-{2-[4-(4-dimethylamino-phenylazo)-benzoylamino]-ethoxy}-ethyl ester (247059-51-4)

Guidance literature:

With 1H-tetrazole;

DOI:10.1080/07328319908044700

Reference yield:

p-methyl red (201858-51-7) → diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 2-{2-[4-(4-dimethylamino-phenylazo)-benzoylamino]-ethoxy}-ethyl ester (247059-51-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium*PF₆; i-Pr₂NEt / dimethylformamide

2: 68 percent / tetrazole

With 1H-tetrazole; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; 1: Acylation / 2: Substitution;

DOI:10.1080/07328319908044700

Reference yield: 87.0%

diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 2-{2-[4-(4-dimethylamino-phenylazo)-benzoylamino]-ethoxy}-ethyl ester (247059-51-4) + C31H30(2)H2N2O7 → C40H47(2)H2N4O8P

Guidance literature:

With N,N-diisopropylamine tetrazolide; In dichloromethane; at 20 ℃;

DOI:10.1080/07328319908044720

upstream raw materials:

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

p-methyl red

Refernces