C₂₇H₃₇N₃O₂

Base Information

• Chemical Name: C₂₇H₃₇N₃O₂
• CAS No.: 301152-69-2
• Molecular Formula: C₂₇H₃₇N₃O₂
• Molecular Weight: 435.61
• Mol file: 301152-69-2.mol

Synonyms:C₂₇H₃₇N₃O₂

Chemical Property of C₂₇H₃₇N₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₃₇N₃O₂

There total 4 articles about C₂₇H₃₇N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

3-chloromethyl-5-methylsalicylaldehyde (192819-68-4) + 1-amino-2-propene (107-11-9,30551-89-4) → C27H37N3O2 (301152-69-2)

Guidance literature:

3-chloromethyl-5-methylsalicylaldehyde; 1-amino-2-propene; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

With sodium tetrahydroborate; In methanol; for 24h; Further stages.;

DOI:10.1021/jo001094y

Reference yield:

2,6-bis(hydroxymethyl)-4-methylphenol (91-04-3) → C27H37N3O2 (301152-69-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 95 percent / conc. H₂SO₄ / acetone / 1 h / 20 °C

2.1: 95 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / 20 °C

3.1: 90 percent / conc. HCl / 12 h

4.1: K₂CO₃ / dimethylformamide / 24 h / 20 °C

4.2: 53 percent / sodium borohydride / methanol / 24 h

With hydrogenchloride; sulfuric acid; potassium carbonate; pyridinium chlorochromate; In dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jo001094y

Reference yield:

(2,2,6-trimethyl-4H-benzo[1,3]dioxin-8-yl)-methanol (140875-58-7) → C27H37N3O2 (301152-69-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 95 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / 20 °C

2.1: 90 percent / conc. HCl / 12 h

3.1: K₂CO₃ / dimethylformamide / 24 h / 20 °C

3.2: 53 percent / sodium borohydride / methanol / 24 h

With hydrogenchloride; potassium carbonate; pyridinium chlorochromate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo001094y

upstream raw materials:

3-chloromethyl-5-methylsalicylaldehyde

1-amino-2-propene

2,6-bis(hydroxymethyl)-4-methylphenol

(2,2,6-trimethyl-4H-benzo[1,3]dioxin-8-yl)-methanol