(2-{2-[4-(5-carbamoyl-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

Base Information

Chemical Name:(2-{2-[4-(5-carbamoyl-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester
CAS No.:374109-29-2
Molecular Formula:C₂₅H₃₀N₂O₆
Molecular Weight:454.523
Hs Code.:

(2-{2-[4-(5-carbamoyl-pentyl)-3-oxo-3,4-dihydro-2<i>H</i>-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

Synonyms:(2-{2-[4-(5-carbamoyl-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

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Chemical Property of (2-{2-[4-(5-carbamoyl-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

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Technology Process of (2-{2-[4-(5-carbamoyl-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

There total 7 articles about (2-{2-[4-(5-carbamoyl-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 374109-32-7
2H-1,4-Benzoxazine-4-hexanoic acid, 3,4-dihydro-2-[2-[2-(2-methoxy-2-oxoethyl)phenoxy]ethyl]-3-oxo-

: 374109-29-2
(2-{2-[4-(5-carbamoyl-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

Guidance literature:: 2H-1,4-Benzoxazine-4-hexanoic acid, 3,4-dihydro-2-[2-[2-(2-methoxy-2-oxoethyl)phenoxy]ethyl]-3-oxo-; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 2h;

With ammonium hydroxide; In dichloromethane; at 20 ℃;
DOI:10.1021/jm0301888

Reference yield:

: 88-75-5,78813-12-4
2-hydroxynitrobenzene

: 374109-29-2
(2-{2-[4-(5-carbamoyl-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 62 percent / potassium carbonate / dimethylformamide / 17 h / 20 °C

2.1: H₂ / Pd/C / ethanol / 3 h / 20 °C / 2327.17 Torr

3.1: 46.8 g / imidazole / dimethylformamide / 15 h / 0 - 20 °C

4.1: sodium hydride / dimethylformamide / 0 °C

4.2: dimethylformamide / 0 - 20 °C

4.3: aq. CH₃SO₃H / methanol / 20 °C

5.1: tributylphosphine; 1,1'-(azodicarbonyl)dipiperidine / benzene / 20 °C

6.1: H₂ / Pd/C / ethanol / 3 h / 20 °C / 2585.74 Torr

7.1: 1,1'-carbonyldiimidazole / CH₂Cl₂ / 2 h / 20 °C

7.2: aq. NH₄OH / CH₂Cl₂ / 20 °C

With 1H-imidazole; tributylphosphine; hydrogen; sodium hydride; potassium carbonate; 1,1'-carbonyldiimidazole; 1,1'-azodicarbonyl-dipiperidine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; benzene; 5.1: Mitsunobu reaction;
DOI:10.1021/jm0301888

Reference yield:

: 161176-99-4
3,4-Dihydro-2-(2-hydroxyethyl)-3-oxo-2H-1,4-benzoxazine

: 374109-29-2
(2-{2-[4-(5-carbamoyl-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 46.8 g / imidazole / dimethylformamide / 15 h / 0 - 20 °C

2.1: sodium hydride / dimethylformamide / 0 °C

2.2: dimethylformamide / 0 - 20 °C

2.3: aq. CH₃SO₃H / methanol / 20 °C

3.1: tributylphosphine; 1,1'-(azodicarbonyl)dipiperidine / benzene / 20 °C

4.1: H₂ / Pd/C / ethanol / 3 h / 20 °C / 2585.74 Torr

5.1: 1,1'-carbonyldiimidazole / CH₂Cl₂ / 2 h / 20 °C

5.2: aq. NH₄OH / CH₂Cl₂ / 20 °C

With 1H-imidazole; tributylphosphine; hydrogen; sodium hydride; 1,1'-carbonyldiimidazole; 1,1'-azodicarbonyl-dipiperidine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; benzene; 3.1: Mitsunobu reaction;
DOI:10.1021/jm0301888