(3R)-methyl 3-[(tert-butyldimethylsilyl)oxy]-2,2-dichloro-3-phenylpropanoate

Base Information

Chemical Name:(3R)-methyl 3-[(tert-butyldimethylsilyl)oxy]-2,2-dichloro-3-phenylpropanoate
CAS No.:1394236-85-1
Molecular Formula:C₁₆H₂₄Cl₂O₃Si
Molecular Weight:363.356
Hs Code.:

Synonyms:(3R)-methyl 3-[(tert-butyldimethylsilyl)oxy]-2,2-dichloro-3-phenylpropanoate

Suppliers and Price of (3R)-methyl 3-[(tert-butyldimethylsilyl)oxy]-2,2-dichloro-3-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-methyl 3-[(tert-butyldimethylsilyl)oxy]-2,2-dichloro-3-phenylpropanoate

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Technology Process of (3R)-methyl 3-[(tert-butyldimethylsilyl)oxy]-2,2-dichloro-3-phenylpropanoate

There total 2 articles about (3R)-methyl 3-[(tert-butyldimethylsilyl)oxy]-2,2-dichloro-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 27607-77-8
trimethylsilyl trifluoromethanesulfonate

: (3R)-methyl 2,2-dichloro-3-hydroxy-3-phenylpropionate

: 1394236-85-1
(3R)-methyl 3-[(tert-butyldimethylsilyl)oxy]-2,2-dichloro-3-phenylpropanoate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol301988d

Reference yield:

: 100-52-7
benzaldehyde

: 1394236-85-1
(3R)-methyl 3-[(tert-butyldimethylsilyl)oxy]-2,2-dichloro-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: (S)-4-Isopropyl-3-tosyl-[1,3,2]oxazaborolidin-5-one / dichloromethane / -78 °C / Inert atmosphere

2: 2,6-dimethylpyridine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; (S)-4-Isopropyl-3-tosyl-[1,3,2]oxazaborolidin-5-one; In dichloromethane; 1: |Mukaiyama Aldol Addition;
DOI:10.1021/ol301988d

Reference yield:

: 1394236-85-1
(3R)-methyl 3-[(tert-butyldimethylsilyl)oxy]-2,2-dichloro-3-phenylpropanoate

: C₁₅H₂₂Cl₂O₂Si

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol301988d