ethyl 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylate

Base Information

Chemical Name:ethyl 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylate
CAS No.:1282549-79-4
Molecular Formula:C₂₆H₃₀N₂O₅S
Molecular Weight:482.601
Hs Code.:

Synonyms:ethyl 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylate

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Chemical Property of ethyl 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylate

Chemical Property:

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Technology Process of ethyl 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylate

There total 3 articles about ethyl 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6436-59-5
ethyl 2-methylthiazole-4-carboxylate

: 1282549-79-4
ethyl 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane; water / 1.67 h / Irradiation; Reflux

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate / methanol; acetonitrile / 1 h / 20 °C / Cooling with ice

3.1: triethylamine / acetonitrile / 1 h / 20 °C / Cooling with ice/methanol

With N-Bromosuccinimide; potassium carbonate; triethylamine; dibenzoyl peroxide; In methanol; tetrachloromethane; water; acetonitrile;

Reference yield:

: 1282549-53-4
ethyl 2-{[(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylate

: 34523-76-7
3,5-dimethoxy-4-methylbenzoyl chloride

: 1282549-79-4
ethyl 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylate

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 1h; Cooling with ice/methanol;

Reference yield:

: 78502-71-3
ethyl 2-(bromomethyl)-1,3-thiazole-4-carboxylate

: 1282549-79-4
ethyl 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol; acetonitrile / 1 h / 20 °C / Cooling with ice

2: triethylamine / acetonitrile / 1 h / 20 °C / Cooling with ice/methanol

With potassium carbonate; triethylamine; In methanol; acetonitrile;