78502-71-3

Basic information

• Product Name: ETHYL 2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE
• Synonyms: ETHYL 2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE;ETHYL 2-(BROMOMETHYL)THIAZOLE-4-CARBOXYLATE;4-Thiazolecarboxylic acid, 2-(bromomethyl)-, ethyl ester
• CAS NO: 78502-71-3
• Molecular Formula: C₇H₈BrNO₂S
• Molecular Weight: 250.11
• Mol File: 78502-71-3.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 290.8±20.0 °C(Predicted)
• Appearance: /
• Density: 1.602±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: -0.45±0.10(Predicted)
• CAS DataBase Reference: ETHYL 2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE(78502-71-3)
• EPA Substance Registry System: ETHYL 2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE(78502-71-3)

Safety Data

• Hazardous Substances Data: 78502-71-3(Hazardous Substances Data)

Usage

General Description

ETHYL 2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE is a chemical compound consisting of an ethyl group attached to a 1,3-thiazole ring with a bromomethyl group at position 2 and a carboxylate group at position 4. ETHYL 2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE is commonly used in organic synthesis as a reagent for the preparation of thiazole derivatives, which have potential pharmaceutical applications. It is also used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. Additionally, it has been studied for its potential antimicrobial and pesticidal properties. However, it is important to handle this compound with care as it is a potentially hazardous chemical that should be used in a controlled laboratory setting.

Upstream product

• 6436-59-5 ethyl 2-methylthiazole-4-carboxylate 
• 94-36-0 dibenzoyl peroxide 

Downstream Products

• 1351369-84-0 C₂₅H₂₈N₂O₃S 
• 1282549-56-7 ethyl 2-{[(tert-butoxycarbonyl)(3-phenylpropyl)aminomethyl]methyl}-1,3-thiazole-4-carboxylate 
• 1282544-10-8 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-N-(phenylsulfonyl)-1,3-thiazole-4-carboxamide 
• 1282544-36-8 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-N-{[(2-hydroxyethyl)amino]sulfonyl}-1,3-thiazole-4-carboxamide 
• 1282544-33-5 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-N-[(3-oxopyrrolidin-1-yl)sulfonyl]-1,3-thiazole-4-carboxamide 
• 1282544-16-4 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-N-[(3-hydroxypyrrolidin-1-yl)sulfonyl]-1,3-thiazole-4-carboxamide 
• 1282549-96-5 N-[(3-{[tert-butyl (dimethyl)silyl]oxy}pyrrolidin-1-yl)sulfonyl]-2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxamide 
• 1282549-22-7 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylic acid 
• 1282549-79-4 ethyl 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylate 
• 1282549-53-4 ethyl 2-{[(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylate 
• 1263298-23-2 Ethyl 2-(6-fluoro-5-methoxy-2-phenylindol-1-ylmethyl)thiazole-4-carboxylate 
• 1256240-34-2 2-hydroxymethylthiazole-4-carboxylic acid methyl ester 
• 1204746-22-4 2-{(4-Methyl-3,5-diphenyl-1H-pyrazol-1-yl)methyl}thiazole-4-carboxylic acid 
• 1204771-07-2 ethyl 2-((3-phenyl-6-(trifluoromethyl)-1H-indazol-1-yl)methyl)thiazole-4-carboxylate 

Relevant articles and documents

Design, synthesis, and antitumor activity evaluation of pretubulysin analogs

Pretubulysin, a biosynthetic precursor of the tubulysins, shows potent biological activity in a variety of tumor cell lines. Although there are several total synthesis routes to tubulysin and pretubulysin reported, the commercialization still has been hampered due to the complexity of the structure. To find structurally simpler pretubulysin analogs, a series of 2-(3-(methylamino)propyl)thiazole-4-carboxamides are designed and synthesized, and their anticancer activities are screened using MCF-7 (breast cancer), and NCI-H157 (lung cancer) cell lines. Taxol (IC50?=?0.01?μM) and pretubulysin are used as the control. Compounds 8c (IC50?=?0.05?μM, MCF-7; 0.09?μM, NCI-H157) and 8h (IC50?=?0.01?μM, MCF-7; 0.02?μM, NCI-H157) exhibited certain antitumor activities comparable to those of Taxol. The urea analogs of pretubulysin might represent a promising scaffold for the further development of novel antitumor drugs.

Sulfur-containing compound based on glutaryl imide skeleton and application of compound

The present disclosure relates to compound shown in a formula (I) or salts, solvates, isotope-enriched analogs, tautomers, polymorphs, stereoisomers, or mixtures of stereoisomers of the compound, andthe application thereof in the treatment of tumours. The present disclosure also provides tumor treatment application of the compound showed in a formula (I') or pharmaceutically acceptable salts, solvates, isotope-enriched analogs, tautomers, polymorphic substances, stereoisomers, or mixtures of stereoisomers of the compound.

NEW BRADYKININ B1 ANTAGONISTS

The invention relates to compounds of formula (I) where in R1, R1a, R1b, R2, R3 and X, X1, X2, X3 have the meaning as cited in the description and the claims. Said compounds are useful as Bradykinin B1 antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.