tert-butyl (3-endo)-3-[3-(2-methoxyethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate

Base Information

Chemical Name:tert-butyl (3-endo)-3-[3-(2-methoxyethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.:1307254-80-3
Molecular Formula:C₂₁H₃₁NO₄
Molecular Weight:361.481
Hs Code.:

Synonyms:tert-butyl (3-endo)-3-[3-(2-methoxyethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (3-endo)-3-[3-(2-methoxyethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate

Chemical Property:

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Technology Process of tert-butyl (3-endo)-3-[3-(2-methoxyethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate

There total 7 articles about tert-butyl (3-endo)-3-[3-(2-methoxyethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1307254-79-0
C₂₀H₂₉NO₄

: 74-88-4
methyl iodide

: 1307254-80-3
tert-butyl (3-endo)-3-[3-(2-methoxyethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1307254-80-3
tert-butyl (3-endo)-3-[3-(2-methoxyethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water; tetrahydrofuran / 1 h / 20 °C / Cooling with ice

2.1: calcium chloride / methanol / 0.5 h / Cooling with ice

2.2: 1 h

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium hydride; triphenylphosphine; calcium chloride; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: (8-azabicyclo[3.2.1]octan-3-one) hydrochloride

: 1307254-80-3
tert-butyl (3-endo)-3-[3-(2-methoxyethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water; tetrahydrofuran / 1 h / 20 °C / Cooling with ice

2.1: calcium chloride / methanol / 0.5 h / Cooling with ice

2.2: 1 h

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium hydride; triphenylphosphine; calcium chloride; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; mineral oil;