(6S,9R,10S,11S,7E)-11-[(S)-1-(benzyloxy)propan-2-yl]-9-(4-methoxybenzyloxy)-2,2,6,10,13,13,14,14-octamethyl-3,3-diphenyl-4,12-dioxa-3,13-disilapentadec-7-ene

Base Information

Chemical Name:(6S,9R,10S,11S,7E)-11-[(S)-1-(benzyloxy)propan-2-yl]-9-(4-methoxybenzyloxy)-2,2,6,10,13,13,14,14-octamethyl-3,3-diphenyl-4,12-dioxa-3,13-disilapentadec-7-ene
CAS No.:1269830-03-6
Molecular Formula:C₄₉H₇₀O₅Si₂
Molecular Weight:795.263
Hs Code.:

(6S,9R,10S,11S,7E)-11-[(S)-1-(benzyloxy)propan-2-yl]-9-(4-methoxybenzyloxy)-2,2,6,10,13,13,14,14-octamethyl-3,3-diphenyl-4,12-dioxa-3,13-disilapentadec-7-ene

Synonyms:(6S,9R,10S,11S,7E)-11-[(S)-1-(benzyloxy)propan-2-yl]-9-(4-methoxybenzyloxy)-2,2,6,10,13,13,14,14-octamethyl-3,3-diphenyl-4,12-dioxa-3,13-disilapentadec-7-ene

Suppliers and Price of (6S,9R,10S,11S,7E)-11-[(S)-1-(benzyloxy)propan-2-yl]-9-(4-methoxybenzyloxy)-2,2,6,10,13,13,14,14-octamethyl-3,3-diphenyl-4,12-dioxa-3,13-disilapentadec-7-ene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (6S,9R,10S,11S,7E)-11-[(S)-1-(benzyloxy)propan-2-yl]-9-(4-methoxybenzyloxy)-2,2,6,10,13,13,14,14-octamethyl-3,3-diphenyl-4,12-dioxa-3,13-disilapentadec-7-ene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (6S,9R,10S,11S,7E)-11-[(S)-1-(benzyloxy)propan-2-yl]-9-(4-methoxybenzyloxy)-2,2,6,10,13,13,14,14-octamethyl-3,3-diphenyl-4,12-dioxa-3,13-disilapentadec-7-ene

There total 10 articles about (6S,9R,10S,11S,7E)-11-[(S)-1-(benzyloxy)propan-2-yl]-9-(4-methoxybenzyloxy)-2,2,6,10,13,13,14,14-octamethyl-3,3-diphenyl-4,12-dioxa-3,13-disilapentadec-7-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1269830-02-5
(2S,3S,4S,5S)-6-(benzyloxy)-4-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzyloxy)-3,5-dimethylhexanal

: 222545-72-4
2-[(R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-propane-1-sulfonyl]-benzothiazole

: 1269830-03-6
(6S,9R,10S,11S,7E)-11-[(S)-1-(benzyloxy)propan-2-yl]-9-(4-methoxybenzyloxy)-2,2,6,10,13,13,14,14-octamethyl-3,3-diphenyl-4,12-dioxa-3,13-disilapentadec-7-ene

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 23h;
DOI:10.1039/c0ob00491j

Reference yield:

: (3R,4S,5S)-6-(benzyloxy)-1-[(R)-tert-butylsulfinyl]-4-hydroxy-3,5-dimethylhexan-2-one

: 1269830-03-6
(6S,9R,10S,11S,7E)-11-[(S)-1-(benzyloxy)propan-2-yl]-9-(4-methoxybenzyloxy)-2,2,6,10,13,13,14,14-octamethyl-3,3-diphenyl-4,12-dioxa-3,13-disilapentadec-7-ene

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 3 h / -78 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

2.2: 4 h / 0 °C

3.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C

4.1: 2,4,6-trimethyl-pyridine; trifluoroacetic anhydride / acetonitrile / 0.25 h / 0 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 23 h / -78 - 20 °C

With 2,6-dimethylpyridine; 2,4,6-trimethyl-pyridine; sodium hydride; diisobutylaluminium hydride; trifluoroacetic anhydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 4.1: Pummerer reaction;
DOI:10.1039/c0ob00491j

Reference yield:

: 63930-49-4
(R)-3-(benzyloxy)-2-methylpropan-1-ol

: 1269830-03-6
(6S,9R,10S,11S,7E)-11-[(S)-1-(benzyloxy)propan-2-yl]-9-(4-methoxybenzyloxy)-2,2,6,10,13,13,14,14-octamethyl-3,3-diphenyl-4,12-dioxa-3,13-disilapentadec-7-ene

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 1 h / -78 °C

2.1: samarium diiodide / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

2.2: 1.5 h / -78 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 3 h / -78 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

4.2: 4 h / 0 °C

5.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C

6.1: 2,4,6-trimethyl-pyridine; trifluoroacetic anhydride / acetonitrile / 0.25 h / 0 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 23 h / -78 - 20 °C

With 2,6-dimethylpyridine; 2,4,6-trimethyl-pyridine; samarium diiodide; sulfur trioxide pyridine complex; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile; 2.1: Reformatsky reaction / 6.1: Pummerer reaction;
DOI:10.1039/c0ob00491j