5-(4-fluorophenyl)-5,11-dihydro-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione

Base Information

• Chemical Name: 5-(4-fluorophenyl)-5,11-dihydro-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione
• CAS No.: 433693-72-2
• Molecular Formula: C₂₀H₁₂FN₃O₃
• Molecular Weight: 361.332

Synonyms:5-(4-fluorophenyl)-5,11-dihydro-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione

Chemical Property of 5-(4-fluorophenyl)-5,11-dihydro-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione

Chemical Property:

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Technology Process of 5-(4-fluorophenyl)-5,11-dihydro-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione

There total 1 articles about 5-(4-fluorophenyl)-5,11-dihydro-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-Amino-2,6-dihydroxypyrimidine (873-83-6) + 1H-indene-1,3(2H)-dione (606-23-5) + 4-fluorobenzaldehyde (459-57-4) → 5-(4-fluorophenyl)-5,11-dihydro-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione (433693-72-2)

Guidance literature:

With choline chloride; urea; at 80 ℃; for 0.616667h; regioselective reaction; Green chemistry;

DOI:10.3184/175815517X14981249895596

Reference yield: 95.0%

5-(4-fluorophenyl)-5,11-dihydro-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione (433693-72-2) → 5-(4-fluorophenyl)-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione (933234-21-0)

Guidance literature:

With chloranil; In N,N-dimethyl-formamide; for 0.0666667h; Reflux;

DOI:10.1021/jm1009428

upstream raw materials:

4-Amino-2,6-dihydroxypyrimidine

1H-indene-1,3(2H)-dione

4-fluorobenzaldehyde

Downstream raw materials:

5-(4-fluorophenyl)-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione

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