933234-21-0

Basic information

• Product Name: 5-(4-fluorophenyl)-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione
• Synonyms: 5-(4-fluorophenyl)-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione
• CAS NO: 933234-21-0
• Molecular Weight: 359.316
• Mol File: 933234-21-0.mol

Chemical Properties

• CAS DataBase Reference: 5-(4-fluorophenyl)-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-fluorophenyl)-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione(933234-21-0)
• EPA Substance Registry System: 5-(4-fluorophenyl)-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione(933234-21-0)

Safety Data

• Hazardous Substances Data: 933234-21-0(Hazardous Substances Data)

Upstream product

• 606-23-5 1H-indene-1,3(2H)-dione 
• 459-57-4 4-fluorobenzaldehyde 
• 433693-72-2 5-(4-fluorophenyl)-5,11-dihydro-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione 
• 873-83-6 4-Amino-2,6-dihydroxypyrimidine 

Relevant articles and documents

Graphene oxide: A carbocatalyst for the one-pot multicomponent synthesis of 5-aryl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione

A simple, straightforward and efficient method is described for the synthesis of 5-aryl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine- 2,4,6(3H)-trione via one-pot multicomponent reaction of indane-1,3-dione, arylaldehydes and 6-aminopyrimidin-2,4(1H,3H)-dione in presence of catalytic amount of graphene oxide in water. Graphene oxide is a versatile carbocatalyst and this is the first report on its application in a pyrido[2,3-d]pyrimidine synthesis. Good yield, use of readily available starting materials, operational simplicity, easy work-up and eco-friendly re-usable catalyst are the key features of this protocol.

Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents

After the initial discovery of antiproliferative and apoptosis-inducing properties of a camptothecin-inspired pentacycle based on a 1H-indeno[2′, 1′:5,6]dihydropyrido[2,3-d]pyrimidine scaffold, a library of its analogues as well as their oxidized planar c