benzyl (R)-3-(4-trifluoromethylphenylamino)-2-methylpropionylcarbamate

Base Information

• Chemical Name: benzyl (R)-3-(4-trifluoromethylphenylamino)-2-methylpropionylcarbamate
• CAS No.: 1271729-42-0
• Molecular Formula: C₁₉H₁₉F₃N₂O₃
• Molecular Weight: 380.367
• Mol file: 1271729-42-0.mol

Synonyms:benzyl (R)-3-(4-trifluoromethylphenylamino)-2-methylpropionylcarbamate

Chemical Property of benzyl (R)-3-(4-trifluoromethylphenylamino)-2-methylpropionylcarbamate

Chemical Property:

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Technology Process of benzyl (R)-3-(4-trifluoromethylphenylamino)-2-methylpropionylcarbamate

There total 2 articles about benzyl (R)-3-(4-trifluoromethylphenylamino)-2-methylpropionylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methacryloyl-carbamic acid benzyl ester (102254-14-8) + 4-trifluoromethyl-phenylamine; compound with trifluoro-methanesulfonic acid → benzyl (R)-3-(4-trifluoromethylphenylamino)-2-methylpropionylcarbamate (1271729-42-0)

Guidance literature:

With 4-trifluoromethylphenylamine; 2CF₃O₃S^(1-)*C₈₈H₆₆O₂P₄Pd₂⁽²⁺⁾; In tetrahydrofuran; at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/asia.201000740

Reference yield:

4-trifluoromethylphenylamine (455-14-1) + methacryloyl-carbamic acid benzyl ester (102254-14-8) → benzyl (S)-3-(4-trifluoromethylphenylamino)-2-methylpropionylcarbamate + benzyl (R)-3-(4-trifluoromethylphenylamino)-2-methylpropionylcarbamate (1271729-42-0)

Guidance literature:

With 2CF₃O₃S^(1-)*C₄₄H₃₆O₂P₂Pd⁽²⁺⁾; In tetrahydrofuran; at 40 ℃; for 24h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/asia.201000740

upstream raw materials:

4-trifluoromethylphenylamine

methacryloyl-carbamic acid benzyl ester