(S)-3,3'-bis(morpholinomethyl)-2,2'-dihydroxy-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl

Base Information

• Chemical Name: (S)-3,3'-bis(morpholinomethyl)-2,2'-dihydroxy-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl
• CAS No.: 758698-16-7
• Molecular Formula: C₃₀H₄₀N₂O₄
• Molecular Weight: 492.659
• Mol file: 758698-16-7.mol

Synonyms:(S)-3,3'-bis(morpholinomethyl)-2,2'-dihydroxy-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl

Chemical Property of (S)-3,3'-bis(morpholinomethyl)-2,2'-dihydroxy-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3,3'-bis(morpholinomethyl)-2,2'-dihydroxy-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl

There total 1 articles about (S)-3,3'-bis(morpholinomethyl)-2,2'-dihydroxy-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

morpholine (110-91-8,99108-56-2) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + (S)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-naphthol (39648-74-3,65355-00-2,65355-14-8) → 4-(morpholinomethyl)morpholine (5625-90-1) + (S)-3,3'-bis(morpholinomethyl)-2,2'-dihydroxy-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl (758698-16-7)

Guidance literature:

morpholine; formaldehyd; at 60 ℃; for 13h; Cooling with ice;

(S)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-naphthol; In 1,4-dioxane; at 60 ℃; for 18h; Inert atmosphere;

DOI:10.1002/0471264229.os087.07

Reference yield:

(S)-(C10H9(OH)CH2NC4H8O)2 (758698-16-7,758698-17-8) + diphenylzinc (1078-58-6) → [Zn(C6H5)((S)-(C10H9(OH)CH2NC4H8O)(C10H9(O)CH2NC4H8O))]

Guidance literature:

In ⁽²⁾H₈-toluene; byproducts: benzene; addn. of 1 equiv. of diphenylzinc to binol deriv.; not isolated; detn. by NMR;

DOI:10.1002/anie.200503206

Reference yield:

(S)-(C10H9(OH)CH2NC4H8O)2 (758698-16-7,758698-17-8) + diphenylzinc (1078-58-6) → [Zn4(C6H5)6((S)-(C10H9(O)CH2NC4H8O)2)]

Guidance literature:

In ⁽²⁾H₈-toluene; byproducts: benzene; addn. of 12 equiv. of diphenylzinc to binol deriv.; not isolated; detn. by NMR;

DOI:10.1002/anie.200503206

upstream raw materials:

morpholine

formaldehyd

(S)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-naphthol

Refernces