4-chloro-7-(trimethylsilyl)-3-(4-((trimethylsilyl)ethynyl)phenyl)isoquinoline

Base Information

Chemical Name:4-chloro-7-(trimethylsilyl)-3-(4-((trimethylsilyl)ethynyl)phenyl)isoquinoline
CAS No.:1352803-19-0
Molecular Formula:C₂₃H₂₆ClNSi₂
Molecular Weight:408.09
Hs Code.:

Synonyms:4-chloro-7-(trimethylsilyl)-3-(4-((trimethylsilyl)ethynyl)phenyl)isoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-chloro-7-(trimethylsilyl)-3-(4-((trimethylsilyl)ethynyl)phenyl)isoquinoline

Chemical Property:

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Technology Process of 4-chloro-7-(trimethylsilyl)-3-(4-((trimethylsilyl)ethynyl)phenyl)isoquinoline

There total 8 articles about 4-chloro-7-(trimethylsilyl)-3-(4-((trimethylsilyl)ethynyl)phenyl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1417212-77-1
C₂₇H₃₇LiN₂Si₂

: 1352803-19-0
4-chloro-7-(trimethylsilyl)-3-(4-((trimethylsilyl)ethynyl)phenyl)isoquinoline

Guidance literature:: With hexachloroethane; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

Reference yield: 54.0%

: 1352802-98-2
2-methyl-5-(trimethylsilyl)benzaldehyde tert-butylimine

: 75867-40-2
4-[2-(trimethylsilyl)ethynyl]benzonitrile

: 1352803-19-0
4-chloro-7-(trimethylsilyl)-3-(4-((trimethylsilyl)ethynyl)phenyl)isoquinoline

Guidance literature:: 2-methyl-5-(trimethylsilyl)benzaldehyde tert-butylimine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 1.16667h; Inert atmosphere;

4-[2-(trimethylsilyl)ethynyl]benzonitrile; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h; Further stages; Inert atmosphere;
DOI:10.1002/anie.201104769

Reference yield:

: 1352802-80-2
2-methyl-5-(trimethylsilyl)benzaldehyde

: 1352803-19-0
4-chloro-7-(trimethylsilyl)-3-(4-((trimethylsilyl)ethynyl)phenyl)isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzene / 16 h / 80 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 1.17 h / 0 °C / Inert atmosphere

2.2: 0.08 h / -78 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; benzene;
DOI:10.1002/anie.201104769