{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester; hydrochloride

Base Information

• Chemical Name: {4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester; hydrochloride
• CAS No.: 78431-92-2
• Molecular Formula: C₁₄H₂₅Cl₂NO₂*ClH
• Molecular Weight: 346.725

Synonyms:{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester; hydrochloride

Chemical Property of {4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester; hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of {4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester; hydrochloride

There total 2 articles about {4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

{4-[Bis-(2-hydroxy-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester (78431-89-7) → {4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester; hydrochloride (78431-92-2)

Guidance literature:

With thionyl chloride; In chloroform; at 20 ℃; for 1h;

DOI:10.1007/BF00962271

Reference yield:

cis-4-aminocyclohexylacetic acid ethyl ester (76308-15-1) → {4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester; hydrochloride (78431-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / H₂O

2: 75 percent / SOCl₂ / CHCl₃ / 1 h / 20 °C

With thionyl chloride; In chloroform; water;

DOI:10.1007/BF00962271

Reference yield: 90.0%

{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester; hydrochloride (78431-92-2) → {4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester (78432-00-5)

Guidance literature:

With sodium ethanolate; In ethanol;

DOI:10.1007/BF00962271

upstream raw materials:

{4-[Bis-(2-hydroxy-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester

cis-4-aminocyclohexylacetic acid ethyl ester

Downstream raw materials:

{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetic acid; hydrochloride

{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester

C₁₄H₂₅Cl₂NO₃

2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid; hydrochloride

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