2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid; hydrochloride

Base Information

Chemical Name:2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid; hydrochloride
CAS No.:78609-74-2
Molecular Formula:C₁₇H₃₀Cl₂N₂O₃*ClH
Molecular Weight:417.804
Hs Code.:

Synonyms:2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid; hydrochloride

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Chemical Property of 2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid; hydrochloride

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Technology Process of 2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid; hydrochloride

There total 6 articles about 2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 78609-72-0
2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid benzhydryl ester; hydrochloride

: 78609-74-2
2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid; hydrochloride

Guidance literature:: With hydrogenchloride; acetic acid; at 20 ℃;
DOI:10.1007/BF00962271

Reference yield: 61.0%

: 78609-70-8
2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid benzyl ester; hydrochloride

: 78609-74-2
2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid; hydrochloride

Guidance literature:: With hydrogen; palladium; In ethanol;
DOI:10.1007/BF00962271

Reference yield:

: 78431-89-7
{4-[Bis-(2-hydroxy-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester

: 78609-74-2
2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / SOCl₂ / CHCl₃ / 1 h / 20 °C

2: 80 percent / aq. HCl / 1.5 h / Heating

3: 90 percent / 1,3-dicyclohexylcarbodiimide

4: 61 percent / H₂ / Pd / ethanol

With hydrogenchloride; thionyl chloride; hydrogen; dicyclohexyl-carbodiimide; palladium; In ethanol; chloroform;
DOI:10.1007/BF00962271