17-methyl-3-methoxy-4,5α-epoxy-6α-O-acetyl-7α-phenylmorphinan

Base Information

Chemical Name:17-methyl-3-methoxy-4,5α-epoxy-6α-O-acetyl-7α-phenylmorphinan
CAS No.:212553-49-6
Molecular Formula:C₂₆H₂₉NO₄
Molecular Weight:419.521
Hs Code.:

Synonyms:17-methyl-3-methoxy-4,5α-epoxy-6α-O-acetyl-7α-phenylmorphinan

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Chemical Property of 17-methyl-3-methoxy-4,5α-epoxy-6α-O-acetyl-7α-phenylmorphinan

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Technology Process of 17-methyl-3-methoxy-4,5α-epoxy-6α-O-acetyl-7α-phenylmorphinan

There total 4 articles about 17-methyl-3-methoxy-4,5α-epoxy-6α-O-acetyl-7α-phenylmorphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 108-24-7
acetic anhydride

: 212553-46-3
17-methyl-3-methoxy-4,5α-epoxy-7α-phenylmorphinan-6α-ol

: 212553-49-6
17-methyl-3-methoxy-4,5α-epoxy-6α-O-acetyl-7α-phenylmorphinan

Guidance literature:: With acetic acid; for 24h; Heating;
DOI:10.1021/jm9802214

Reference yield:

: 2217-79-0
diphenyliodonium iodide

: 212553-49-6
17-methyl-3-methoxy-4,5α-epoxy-6α-O-acetyl-7α-phenylmorphinan

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) lithium hexamethyldisilazane / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, DMF, -45 deg C, 2 h

2: 87 percent / NaBH₄ / ethanol / 22 h / Ambient temperature

3: 99 percent / glacial AcOH / 24 h / Heating

With sodium tetrahydroborate; acetic acid; lithium hexamethyldisilazane; In ethanol;
DOI:10.1021/jm9802214

Reference yield:

: 162336-11-0
7α-Phenylhydrocodone

: 212553-49-6
17-methyl-3-methoxy-4,5α-epoxy-6α-O-acetyl-7α-phenylmorphinan

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / NaBH₄ / ethanol / 22 h / Ambient temperature

2: 99 percent / glacial AcOH / 24 h / Heating

With sodium tetrahydroborate; acetic acid; In ethanol;
DOI:10.1021/jm9802214