{[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)[3-({1-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1H-indol-4-yl}oxy)propyl]amine

Base Information

Chemical Name:{[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)[3-({1-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1H-indol-4-yl}oxy)propyl]amine
CAS No.:847990-41-4
Molecular Formula:C₃₉H₃₉ClF₃N₃O₂S
Molecular Weight:706.272
Hs Code.:

Synonyms:{[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)[3-({1-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1H-indol-4-yl}oxy)propyl]amine

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Chemical Property of {[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)[3-({1-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1H-indol-4-yl}oxy)propyl]amine

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Technology Process of {[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)[3-({1-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1H-indol-4-yl}oxy)propyl]amine

There total 3 articles about {[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)[3-({1-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1H-indol-4-yl}oxy)propyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 123-90-0
Thiomorpholin

: 847990-39-0
(4-{3-[(2-chloro-3-trifluoromethyl-benzyl)-2,2-diphenylmethyl-amino]-methyl-propoxy}-indol-1-yl)acetic acid hydrochloride

: 847990-41-4
{[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)[3-({1-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1H-indol-4-yl}oxy)propyl]amine

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane;

Reference yield:

: 93118-03-7
2-chloro-3-trifluoromethylbenzaldehyde

: 847990-41-4
{[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)[3-({1-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1H-indol-4-yl}oxy)propyl]amine

Guidance literature:: Multi-step reaction with 6 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane

2: potassium carbonate / acetonitrile / Heating / reflux

3: potassium carbonate / acetonitrile / 90 °C

4: sodium hydride / N,N-dimethyl-formamide / 0.25 h

5: hydrogenchloride / diethyl ether / 0.5 h

6: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane

With hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; acetic acid; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 612499-61-3
(3-bromopropyl)({ [2-chloro-3-(trifluoromethyl)phenyl]methyl})(2,2-diphenylethyl)amine

: 847990-41-4
{[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)[3-({1-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1H-indol-4-yl}oxy)propyl]amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 90 °C

2: sodium hydride / N,N-dimethyl-formamide / 0.25 h

3: hydrogenchloride / diethyl ether / 0.5 h

4: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane

With hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; potassium carbonate; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;