123-90-0

Basic information

• Product Name: Thiomorpholine
• Synonyms: Tetrahydro-2H-1,4-thiazine, Thiamorpholine;Thiomorpholine,97%;Thiomorpholine ,98%;1,4-Thiazinane, Tetrahydro-2H-1,4-thiazine;ThioMorpholine, 97% 5GR;ThioMorpholine 98.0%Min;ThioMorpholine 98%;4-THIOMORPHOLINE
• CAS NO: 123-90-0
• Molecular Formula: C₄H₉NS
• Molecular Weight: 103.19
• EINECS: 204-660-2
• Product Categories: Morpholines & Thiomorpholines;Morpholines & Thiomorpholines;Ring Systems;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Others;S-Containing;Pyrimidines
• Mol File: 123-90-0.mol
• Article Data: 27

Chemical Properties

• Melting Point: 166-168
• Boiling Point: 169 °C(lit.)
• Flash Point: 140 °F
• Appearance: clear colorless to yellow liquid
• Density: 1.026 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.5mmHg at 25°C
• Refractive Index: n20/D 1.538(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: organic solvents: miscible(lit.)
• PKA: 9.14±0.20(Predicted)
• Water Solubility: Miscible with waterMiscible with water and organic solvents.
• Sensitive: Air Sensitive
• Merck: 14,9300
• BRN: 102550
• CAS DataBase Reference: Thiomorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: Thiomorpholine(123-90-0)
• EPA Substance Registry System: Thiomorpholine(123-90-0)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-37-36/37/38-R37-R34
• Safety Statements: 26-36/37/39-45-36-S45-S36/37/39-S26
• RIDADR: UN 3267 8/PG 3
• WGK Germany: 3
• F: 10-13-23
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 123-90-0(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to yellow liquid

Uses

Different sources of media describe the Uses of 123-90-0 differently. You can refer to the following data:
1. Organic synthesis.
2. Thiomorpholine is used as an intermediate for blonanserin. It is used in the preparation of pyrrole derivatives, which acts as a antimycobacterial agent. It is further involved in the hypocholesterolemic activity.

Definition

ChEBI: A saturated organic heteromonocyclic parent that is an analogue of morpholine where the oxygen atom is replaced by sulfur.

General Description

Thiomorpholine forms complexes with Cu(II), Pt(II) and Ni(II) salts and their catalytic activity has been investigated.

Purification Methods

Purify it by vacuum distillation. The hydrochloride has m 179o (from isoPrOH or EtOH/Et2O/HCl). [Davies J Chem Soc 306 1920, Beilstein 27 II 4, 2 III/IV 636.]

InChI:InChI=1/C4H9NS/c1-3-6-4-2-5-1/h5H,1-4H2/p+1

Upstream product

• 60-23-1 Cysteamine 
• 45695-98-5 thiomorpholinyl dithiocarbamate 
• 20196-21-8 3-thiomorpholinone 
• 111-42-2 2,2'-iminobis[ethanol] 
• 1217491-78-5 C₁₄H₁₇N₃OS₂*ClH 
• 1217491-62-7 C₁₄H₁₉N₃O₂S₂ 
• 64-17-5 ethanol 
• 334-22-5 N,N-bis(chloro-2-ethyl)amine 
• 106-93-4 ethylene dibromide 
• 124-02-7 diallylamine 
• 505-60-2 bis (2-chloroethyl) sulphide 

Downstream Products

• 101353-93-9 2-thiomorpholin-4-yl-N-(2,4,6-trimethyl-phenyl)-acetamide 
• 21427-52-1 N-phenyl-N’-thiomorpholinethiourea 
• 133024-63-2 N-ethylthiomorpholine 
• 64039-05-0 4,4-dimethyl-thiomorpholinium; iodide 
• 40281-18-3 1,2-diphenyl-3-thiomorpholin-4-yl-propan-1-one 
• 56392-82-6 4-(6-chloro-pyridazin-3-yl)-thiomorpholine 
• 38277-09-7 2-phenyl-5,8-bis-thiomorpholin-4-yl-pyrimido[4,5-d]pyridazine 
• 745720-16-5 2-Thiomorpholinomethylbenzophenon 
• 72662-53-4 2-methyl-1,3-bis-(thiomorpholine-4-carbonylamino)-benzene 
• 19199-34-9 4-[3-(4-chloro-phenyl)-acryloyl]-thiomorpholine 
• 25345-53-3 2-(thiomorpholin-4-yl-acetoxy)-benzoic acid tert-butyl ester 
• 50916-06-8 4-(4-acetoxy-3,5-dimethoxy-benzoyl)-thiomorpholine 
• 21427-53-2 thiomorpholine-4-carbothioic acid 4-methyl-anilide 
• 72662-47-6 thiomorpholine-4-carboxylic acid 4-chloro-anilide 

Related news

Research paperSynthesis and biological evaluation of novel indole-pyrimidine hybrids bearing morpholine and Thiomorpholine (cas 123-90-0) moieties09/24/2019

Based on our previous screening hit compound 1, a series of novel indole-pyrimidine hybrids possessing morpholine or thiomorpholine moiety were synthesized via an efficient one-pot multistep synthetic method. The antiproliferative activities of the synthesized compounds were evaluated in vitro a...detailed

Design, synthesis and primary activity of Thiomorpholine (cas 123-90-0) derivatives as DPP-IV inhibitors09/10/2019

Thirteen thiomorpholine-bearing compounds were designed and synthesized as dipeptidyl peptidase IV (DPP-IV) inhibitors, with natural and non-natural l-amino acids as the starting materials. Their structures were characterized by 1H NMR, 13C NMR and HR-MS. The target compounds were screened for t...detailed

Amides of non-steroidal anti-inflammatory drugs with Thiomorpholine (cas 123-90-0) can yield hypolipidemic agents with improved anti-inflammatory activity09/08/2019

Novel amides of non steroidal anti-inflammatory drugs (NSAIDs), α-lipoic acid and indole-3-acetic acid with thiomorpholine were synthesised by a simple method and at high yields (60–92%). All the NSAID derivatives highly decreased lipidemic indices in the plasma of Triton treated hyperlipidemi...detailed

Relevant articles and documents

-

-

Preparation and chemical properties of 5-dialkylaminomethylhydantoins and 2-thio-analogues

An efficient procedure for the preparation of 5- dialkylaminomethylhydantoins 3, which are easily obtained from cyclization of the corresponding urea derivatives 2 starting with β-aminoalanines 1, is described. Methylenehydantoin and the corresponding 2-t

An annulation reaction for the synthesis of morpholines, thiomorpholines, and piperazines from β-heteroatom amino compounds and vinyl sulfonium salts

(Chemical Equation Presented) Heterocycling: Diphenyl vinyl sulfonium salt 1 acts first as an electrophile, then a base, and then again as an electrophile in this operationally simple, high yielding, one-pot synthesis of pharmacologically important morpholines, thiomorpholines, and piperazines. Compound 1 is an excellent synthon for the 1,2-ethane dication.