N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-4-methyl-3-morpholinecarboxamide

Base Information

• Chemical Name: N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-4-methyl-3-morpholinecarboxamide
• CAS No.: 1361330-04-2
• Molecular Formula: C₂₉H₃₂FN₅O₅S
• Molecular Weight: 581.668
• Mol file: 1361330-04-2.mol

Synonyms:N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-4-methyl-3-morpholinecarboxamide

Chemical Property of N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-4-methyl-3-morpholinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-4-methyl-3-morpholinecarboxamide

There total 6 articles about N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-4-methyl-3-morpholinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-4-methyl-3-morpholinecarboxamide (1361330-51-9) → N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-4-methyl-3-morpholinecarboxamide (1361330-05-3) + N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-4-methyl-3-morpholinecarboxamide (1361330-04-2)

Guidance literature:

With Chiralpak IA column; In ethanol; n-heptane; Resolution of racemate;

Reference yield:

2-fluoro-6-methoxybenzonitrile (94088-46-7) → N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-4-methyl-3-morpholinecarboxamide (1361330-05-3) + N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-4-methyl-3-morpholinecarboxamide (1361330-04-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrazine hydrate / butan-1-ol / 18 h / Reflux; Inert atmosphere

2.1: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

3.1: pyridine / 21 h / 21 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 °C

5.1: HATU / N,N-dimethyl-formamide / 0.05 h / Inert atmosphere

5.2: 0.05 h

5.3: 3 h

6.1: Chiralpak IA column / n-heptane; ethanol / Resolution of racemate

With pyridine; lithium aluminium tetrahydride; hydrazine hydrate; HATU; potassium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; n-heptane; dimethyl sulfoxide; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

4-(methyloxy)-1H-indazol-3-amine (886362-07-8) → N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-4-methyl-3-morpholinecarboxamide (1361330-05-3) + N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-4-methyl-3-morpholinecarboxamide (1361330-04-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

2.1: pyridine / 21 h / 21 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 °C

4.1: HATU / N,N-dimethyl-formamide / 0.05 h / Inert atmosphere

4.2: 0.05 h

4.3: 3 h

5.1: Chiralpak IA column / n-heptane; ethanol / Resolution of racemate

With pyridine; lithium aluminium tetrahydride; HATU; potassium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; n-heptane; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

2-fluoro-6-methoxybenzonitrile

4-(methyloxy)-1H-indazol-3-amine

3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}-benzonitrile

N-[1-[(3-cyanophenyl)methyl]-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide