(R)-tert-butyl (1-benzyl-5-chloro-3-(diphenoxyphosphoryl)-2-oxoindolin-3-yl)carbamate

Base Information

Chemical Name:(R)-tert-butyl (1-benzyl-5-chloro-3-(diphenoxyphosphoryl)-2-oxoindolin-3-yl)carbamate
CAS No.:1568924-68-4
Molecular Formula:C₃₂H₃₀ClN₂O₆P
Molecular Weight:605.027
Hs Code.:

Synonyms:(R)-tert-butyl (1-benzyl-5-chloro-3-(diphenoxyphosphoryl)-2-oxoindolin-3-yl)carbamate

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Chemical Property of (R)-tert-butyl (1-benzyl-5-chloro-3-(diphenoxyphosphoryl)-2-oxoindolin-3-yl)carbamate

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Technology Process of (R)-tert-butyl (1-benzyl-5-chloro-3-(diphenoxyphosphoryl)-2-oxoindolin-3-yl)carbamate

There total 2 articles about (R)-tert-butyl (1-benzyl-5-chloro-3-(diphenoxyphosphoryl)-2-oxoindolin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 4712-55-4
diphenyl hydrogen phosphite

: 1426931-80-7
tert-butyl (1-benzyl-5-chloro-2-oxoindolin-3-ylidene)carbamate

: 1568924-68-4
(R)-tert-butyl (1-benzyl-5-chloro-3-(diphenoxyphosphoryl)-2-oxoindolin-3-yl)carbamate

Guidance literature:: tert-butyl (1-benzyl-5-chloro-2-oxoindolin-3-ylidene)carbamate; With 3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-(((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione; In dichloromethane; at -10 ℃; for 0.25h; Schlenk technique; Inert atmosphere;

diphenyl hydrogen phosphite; In dichloromethane; at -10 ℃; for 24h; enantioselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1039/c3ob42026d

Reference yield:

: 4712-55-4
diphenyl hydrogen phosphite

: 1426931-80-7
tert-butyl (1-benzyl-5-chloro-2-oxoindolin-3-ylidene)carbamate

: 1568924-68-4
(R)-tert-butyl (1-benzyl-5-chloro-3-(diphenoxyphosphoryl)-2-oxoindolin-3-yl)carbamate

: C₃₂H₃₀ClN₂O₆P

Guidance literature:: tert-butyl (1-benzyl-5-chloro-2-oxoindolin-3-ylidene)carbamate; With titanium(IV) isopropylate; C₈₀H₁₂₀N₄O₁₆; In toluene; at 20 ℃; for 0.5h; Inert atmosphere; Molecular sieve;

diphenyl hydrogen phosphite; In toluene; at 20 ℃; for 12h; Overall yield = 84 %; Optical yield = 68 %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1016/j.apcata.2015.12.037