1-(1-acetyl piperidin-3-yl)-5-amino-3-[4-(4-chloro-3-methylphenoxy)phenyl]-1H-pyrazole-4-carbonitrile

Base Information

Chemical Name:1-(1-acetyl piperidin-3-yl)-5-amino-3-[4-(4-chloro-3-methylphenoxy)phenyl]-1H-pyrazole-4-carbonitrile
CAS No.:1609467-73-3
Molecular Formula:C₂₄H₂₄ClN₅O₂
Molecular Weight:449.94
Hs Code.:

Synonyms:1-(1-acetyl piperidin-3-yl)-5-amino-3-[4-(4-chloro-3-methylphenoxy)phenyl]-1H-pyrazole-4-carbonitrile

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Chemical Property of 1-(1-acetyl piperidin-3-yl)-5-amino-3-[4-(4-chloro-3-methylphenoxy)phenyl]-1H-pyrazole-4-carbonitrile

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Technology Process of 1-(1-acetyl piperidin-3-yl)-5-amino-3-[4-(4-chloro-3-methylphenoxy)phenyl]-1H-pyrazole-4-carbonitrile

There total 6 articles about 1-(1-acetyl piperidin-3-yl)-5-amino-3-[4-(4-chloro-3-methylphenoxy)phenyl]-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609467-72-2
1-(3-hydrazinylpiperidin-1-yl)ethanone hydrochloride

: 1609467-70-0
2-((4-(4-chloro-3-methylphenoxy)phenyl)(methoxy)methylene)-malononitrile

: 1609467-73-3
1-(1-acetyl piperidin-3-yl)-5-amino-3-[4-(4-chloro-3-methylphenoxy)phenyl]-1H-pyrazole-4-carbonitrile

Guidance literature:: With triethylamine; at 20 ℃; for 18h;

Reference yield:

: 129644-20-8
1-[4-(4-chloro-3-methylphenoxy)phenyl]ethanone

: 1609467-73-3
1-(1-acetyl piperidin-3-yl)-5-amino-3-[4-(4-chloro-3-methylphenoxy)phenyl]-1H-pyrazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hypochlorite / ethanol / 20 °C

2.1: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

3.2: 3 h / Reflux

4.1: triethylamine / 18 h / 20 °C

With sodium hypochlorite; oxalyl dichloride; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 925005-02-3
4-(4-chloro-3-methylphenoxy)benzoic acid

: 1609467-73-3
1-(1-acetyl piperidin-3-yl)-5-amino-3-[4-(4-chloro-3-methylphenoxy)phenyl]-1H-pyrazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

2.2: 3 h / Reflux

3.1: triethylamine / 18 h / 20 °C

With oxalyl dichloride; sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;