DMDP

Base Information

• Chemical Name: DMDP
• CAS No.: 57010-18-1
• Molecular Formula: C28H35NO2S2*ClH
• Molecular Weight: 518.184
• Mol file: 57010-18-1.mol

Synonyms:[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-[3-(2-naphthalen-2-yl-[1,3]dithian-2-yl)-propyl]-amine;hydrochloride;

Chemical Property of DMDP

Chemical Property:

• PSA: 72.30000
• LogP: 7.63660

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DMDP

There total 4 articles about DMDP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(3-chloropropyl)-3,4-dimethoxy-N-methylphenethylamine (36770-74-8) + 2-(naphthalen-2-yl)-1,3-dithiane (57009-73-1) → N-(3,4-dimethoxyphenetyl)-N-methyl-2-(2-naphthyl)-m-dithiane-2-propylamine hydrochloride (57010-18-1)

Guidance literature:

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; hexane; for 2h; Ambient temperature;

DOI:10.1016/0223-5234(89)90053-6

Reference yield:

2-naphthalenylmagnesium bromide (21473-01-8) → N-(3,4-dimethoxyphenetyl)-N-methyl-2-(2-naphthyl)-m-dithiane-2-propylamine hydrochloride (57010-18-1)

Guidance literature:

Multi-step reaction with 3 steps

2: 97 percent / anhydrous SnCl₂ / tetrahydrofuran

3: 92 percent / 1.) n-BuLi; 2.) HCl/dioxane / hexane; tetrahydrofuran / 2 h / Ambient temperature

With hydrogenchloride; n-butyllithium; tin(ll) chloride; In tetrahydrofuran; hexane;

DOI:10.1016/0223-5234(89)90053-6

Reference yield:

β-naphthaldehyde (66-99-9) → N-(3,4-dimethoxyphenetyl)-N-methyl-2-(2-naphthyl)-m-dithiane-2-propylamine hydrochloride (57010-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / boron trifluoride etherate / CHCl₃ / 0 °C

2: 92 percent / 1.) n-BuLi; 2.) HCl/dioxane / hexane; tetrahydrofuran / 2 h / Ambient temperature

With hydrogenchloride; n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; chloroform;

DOI:10.1016/0223-5234(89)90053-6

upstream raw materials:

N-(3-chloropropyl)-3,4-dimethoxy-N-methylphenethylamine

2-(naphthalen-2-yl)-1,3-dithiane

2-naphthalenylmagnesium bromide

β-naphthaldehyde