(4R)-3-((2R,3S,E)-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-hydroxypent-4-enoyl)-4-isopropyloxazolidin-2-one

Base Information

Chemical Name:(4R)-3-((2R,3S,E)-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-hydroxypent-4-enoyl)-4-isopropyloxazolidin-2-one
CAS No.:1164114-95-7
Molecular Formula:C₅₂H₈₅NO₁₂Si₂
Molecular Weight:972.417
Hs Code.:

(4R)-3-((2R,3S,E)-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-hydroxypent-4-enoyl)-4-isopropyloxazolidin-2-one

Synonyms:(4R)-3-((2R,3S,E)-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-hydroxypent-4-enoyl)-4-isopropyloxazolidin-2-one

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Chemical Property of (4R)-3-((2R,3S,E)-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-hydroxypent-4-enoyl)-4-isopropyloxazolidin-2-one

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Technology Process of (4R)-3-((2R,3S,E)-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-hydroxypent-4-enoyl)-4-isopropyloxazolidin-2-one

There total 1 articles about (4R)-3-((2R,3S,E)-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-hydroxypent-4-enoyl)-4-isopropyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1055224-29-7
(R)-3-butyryl-4-isopropyloxazolidin-2-one

: 1164114-94-6
(E)-3-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)acrylaldehyde

: 1164114-95-7
(4R)-3-((2R,3S,E)-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-hydroxypent-4-enoyl)-4-isopropyloxazolidin-2-one

Guidance literature:: (R)-3-butyryl-4-isopropyloxazolidin-2-one; With di-n-butylboryl trifluoromethanesulfonate; triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

(E)-3-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)acrylaldehyde; In dichloromethane; at -78 - -20 ℃; Inert atmosphere;

With water; sodium hydrogencarbonate; In dichloromethane; at -20 ℃; optical yield given as %de;
DOI:10.1021/ol900757k

Reference yield: 99.0%

: 1164114-95-7
(4R)-3-((2R,3S,E)-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-hydroxypent-4-enoyl)-4-isopropyloxazolidin-2-one

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 1164115-14-3
C₅₈H₉₉NO₁₂Si₃

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol900757k DOI:10.1002/chem.201000104