(4R,7S,8S)-8-amino-7-(2,3-difluorophenyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-4-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

Base Information

Chemical Name:(4R,7S,8S)-8-amino-7-(2,3-difluorophenyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-4-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate
CAS No.:1409944-02-0
Molecular Formula:C₂₇H₂₅F₅N₆O₃S
Molecular Weight:608.592
Hs Code.:

(4R,7S,8S)-8-amino-7-(2,3-difluorophenyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-4-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

Synonyms:(4R,7S,8S)-8-amino-7-(2,3-difluorophenyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-4-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

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Chemical Property of (4R,7S,8S)-8-amino-7-(2,3-difluorophenyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-4-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

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Technology Process of (4R,7S,8S)-8-amino-7-(2,3-difluorophenyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-4-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

There total 14 articles about (4R,7S,8S)-8-amino-7-(2,3-difluorophenyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-4-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1409944-29-1
(4R,7S,8S)-8-(tert-butoxycarbonylamino)-7-(2,3-difluorophenyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-4-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

: 1409944-02-0
(4R,7S,8S)-8-amino-7-(2,3-difluorophenyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-4-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1409944-26-8
tert-butyl (4R,7S,8S)-7-(2,3-difluorophenyl)-4-hydroxy-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-8-ylcarbamate

: 1409944-02-0
(4R,7S,8S)-8-amino-7-(2,3-difluorophenyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-4-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dihydrogen peroxide / ferrocene / dimethyl sulfoxide / 1.05 h / 20 °C

2: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 3 h / -20 - 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With dihydrogen peroxide; sodium hexamethyldisilazane; trifluoroacetic acid; ferrocene; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1409944-23-5
(E)-methyl 2-((7S,8S)-8-(tert-butoxycarbonylamino)-7-(2,3-difluorophenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-4-ylidene)acetate

: 1409944-02-0
(4R,7S,8S)-8-amino-7-(2,3-difluorophenyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-4-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: ozone / dichloromethane / 0.03 h / -78 °C

2: sodium tetrahydroborate / methanol / 0.5 h / 20 °C

3: dihydrogen peroxide / ferrocene / dimethyl sulfoxide / 1.05 h / 20 °C

4: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 3 h / -20 - 20 °C

5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With sodium tetrahydroborate; dihydrogen peroxide; sodium hexamethyldisilazane; ozone; trifluoroacetic acid; ferrocene; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;