Technology Process of (S)-1,2-difluoro-3-(1-nitrohex-5-en-2-yl)benzene
There total 3 articles about (S)-1,2-difluoro-3-(1-nitrohex-5-en-2-yl)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E)-1-nitrohexa-1,5-diene; (2,3-difluorophenyl)boronic acid;
With
water;
In
1,4-dioxane;
With
sodium hydrogencarbonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine);
acetylacetonatobis(ethylene)rhodium(I);
In
1,4-dioxane; water;
at 20 - 35 ℃;
for 14.03h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N,N,N',N'-tetramethylguanidine / toluene / 1 h / 0 °C
1.2: 2 h / 20 °C
2.1: water / 1,4-dioxane
2.2: 14.03 h / 20 - 35 °C / Inert atmosphere
With
water; N,N,N',N'-tetramethylguanidine;
In
1,4-dioxane; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: methanesulfonyl chloride; triethylamine / 2 h / 20 °C / Inert atmosphere
2: water; sodium hydrogencarbonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); acetylacetonatobis(ethylene)rhodium(I) / 14 h / 20 - 35 °C / Inert atmosphere
With
acetylacetonatobis(ethylene)rhodium(I); water; sodium hydrogencarbonate; methanesulfonyl chloride; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); triethylamine;
DOI:10.1021/acs.orglett.5b02921
