1-cyclohexyl-6-(2-hydroxy-5-methylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Base Information

Chemical Name:1-cyclohexyl-6-(2-hydroxy-5-methylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
CAS No.:1354628-36-6
Molecular Formula:C₂₁H₂₁N₃O
Molecular Weight:331.417
Hs Code.:

Synonyms:1-cyclohexyl-6-(2-hydroxy-5-methylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-cyclohexyl-6-(2-hydroxy-5-methylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

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Technology Process of 1-cyclohexyl-6-(2-hydroxy-5-methylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

There total 3 articles about 1-cyclohexyl-6-(2-hydroxy-5-methylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 38445-23-7
6-methyl-chromen-4-one

: 59661-26-6
5-amino-1-cyclohexyl-1H-pyrrole-3-carbonitrile

: 1354628-36-6
1-cyclohexyl-6-(2-hydroxy-5-methylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Guidance literature:: With chloro-trimethyl-silane; In N,N-dimethyl-formamide; at 90 ℃; for 1h; regioselective reaction; Inert atmosphere;
DOI:10.1039/c1ob06494k

Reference yield: 75.0%

: 59661-26-6
5-amino-1-cyclohexyl-1H-pyrrole-3-carbonitrile

: 89807-39-6
(2E)-3-(dimethylamino)-1-(2-hydroxy-5-methylphenyl)-2-propen-1-one

: 1354628-36-6
1-cyclohexyl-6-(2-hydroxy-5-methylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Guidance literature:: With chloro-trimethyl-silane; In N,N-dimethyl-formamide; at 90 ℃; for 1h; regioselective reaction; Inert atmosphere;
DOI:10.1039/c1ob06494k

Reference yield:

: 89807-39-6
(2E)-3-(dimethylamino)-1-(2-hydroxy-5-methylphenyl)-2-propen-1-one

: 1354628-36-6
1-cyclohexyl-6-(2-hydroxy-5-methylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: chloro-trimethyl-silane / N,N-dimethyl-formamide / 90 - 120 °C / Inert atmosphere

2: chloro-trimethyl-silane / N,N-dimethyl-formamide / 1 h / 90 °C / Inert atmosphere

With chloro-trimethyl-silane; In N,N-dimethyl-formamide;
DOI:10.1039/c1ob06494k