1,4-bis(pyridin-2-ylmethyl)-1,4,7-triazacyclononane

Base Information

Chemical Name:1,4-bis(pyridin-2-ylmethyl)-1,4,7-triazacyclononane
CAS No.:159221-73-5
Molecular Formula:C₁₈H₂₅N₅
Molecular Weight:311.43
Hs Code.:

Synonyms:1,4-bis(pyridin-2-ylmethyl)-1,4,7-triazacyclononane

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Chemical Property of 1,4-bis(pyridin-2-ylmethyl)-1,4,7-triazacyclononane

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Technology Process of 1,4-bis(pyridin-2-ylmethyl)-1,4,7-triazacyclononane

There total 2 articles about 1,4-bis(pyridin-2-ylmethyl)-1,4,7-triazacyclononane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₃₀FeN₈O₃⁽²⁺⁾*2BF₄^(1-)

: 288-13-1
NH-pyrazole

: 159221-73-5
1,4-bis(pyridin-2-ylmethyl)-1,4,7-triazacyclononane

Guidance literature:: C₂₆H₃₀FeN₈O₃⁽²⁺⁾*2BF₄^(1-); With 5%-palladium/activated carbon; hydrogen; In aq. phosphate buffer; at 37 ℃; for 1h;

With sodium hydroxide; pH=13;
DOI:10.1002/ejic.201403183

Reference yield:

: 4377-33-7
2-chloromethylpyridine

: 159221-73-5
1,4-bis(pyridin-2-ylmethyl)-1,4,7-triazacyclononane

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

2: water / Heating

3: potassium carbonate; potassium iodide / acetonitrile / 120 h / Inert atmosphere; Heating

4: hydrogenchloride / 24 h / 20 °C

With hydrogenchloride; water; potassium carbonate; potassium iodide; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.poly.2012.10.029

Reference yield: 92.0%

: 159221-73-5
1,4-bis(pyridin-2-ylmethyl)-1,4,7-triazacyclononane

: tert-butyl N-[4-(2-bromoacetamido)phenyl]carbamate

: tert-butyl N-[4-[2-[4,7-bis(pyridin-2-ylmethyl)-1,4,7-triazonan-1-yl]acetamido]phenyl]carbamate

Guidance literature:: 1,4-bis(pyridin-2-ylmethyl)-1,4,7-triazacyclononane; tert-butyl N-[4-(2-bromoacetamido)phenyl]carbamate; With potassium carbonate; potassium iodide; In acetonitrile; at 20 ℃; for 1h;

In acetonitrile; for 24h; Reflux;
DOI:10.1039/c3ra43726d