Technology Process of 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-1,5,5-trimethylimidazolidine-2,4-dione
There total 12 articles about 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-1,5,5-trimethylimidazolidine-2,4-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
ethanol;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 12 steps
1: potassium carbonate / N,N-dimethyl-formamide / 50 °C
2: N,N-dimethyl-aniline / 18 h / 210 °C
3: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 20 °C
4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 80 °C
5: sodium hydroxide / water; ethanol / 2 h / 0 °C / Reflux
6: thionyl chloride / 2 h / Reflux
7: tetramethylammonium fluoride / 1,2-dimethoxyethane / -78 - 20 °C / Inert atmosphere
8: sodium hydride / tetrahydrofuran / 0 - 20 °C
9: hydrogen; palladium 10% on activated carbon / methanol / 20 °C
10: potassium carbonate / N,N-dimethyl-formamide / 20 °C
11: potassium carbonate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C
12: hydrogenchloride / ethanol; methanol / 1 h / 0 - 20 °C
With
hydrogenchloride; thionyl chloride; palladium 10% on activated carbon; tetramethylammonium fluoride; hydrogen; sodium hydride; potassium carbonate; sodium hydroxide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-aniline; N,N-dimethyl-formamide;
2: |Claisen Rearrangement;
DOI:10.1016/j.bmcl.2015.04.080
- Guidance literature:
-
Multi-step reaction with 6 steps
1: tetramethylammonium fluoride / 1,2-dimethoxyethane / -78 - 20 °C / Inert atmosphere
2: sodium hydride / tetrahydrofuran / 0 - 20 °C
3: hydrogen; palladium 10% on activated carbon / methanol / 20 °C
4: potassium carbonate / N,N-dimethyl-formamide / 20 °C
5: potassium carbonate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C
6: hydrogenchloride / ethanol; methanol / 1 h / 0 - 20 °C
With
hydrogenchloride; palladium 10% on activated carbon; tetramethylammonium fluoride; hydrogen; sodium hydride; potassium carbonate;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2015.04.080
![3-[4-[4-[1,1,1,3,3,3-hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenyloxy]butyl]-1,5,5-trimethylimidazolidine-2,4-dione](/Databaselist/images/loading.webp)
