1-benzyl-3-(2-hydroxyethyl)-3-(hydroxymethyl)-2-oxo-2,3-dihydroindole

Base Information

• Chemical Name: 1-benzyl-3-(2-hydroxyethyl)-3-(hydroxymethyl)-2-oxo-2,3-dihydroindole
• CAS No.: 1229649-01-7
• Molecular Formula: C₁₈H₁₉NO₃
• Molecular Weight: 297.354
• Mol file: 1229649-01-7.mol

Synonyms:1-benzyl-3-(2-hydroxyethyl)-3-(hydroxymethyl)-2-oxo-2,3-dihydroindole

Chemical Property of 1-benzyl-3-(2-hydroxyethyl)-3-(hydroxymethyl)-2-oxo-2,3-dihydroindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 1-benzyl-3-(2-hydroxyethyl)-3-(hydroxymethyl)-2-oxo-2,3-dihydroindole

There total 1 articles about 1-benzyl-3-(2-hydroxyethyl)-3-(hydroxymethyl)-2-oxo-2,3-dihydroindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1'-benzyl-5-hydroxy-2',3',4,5-tetrahydro-2H-spiro[furan-3,3'-indolin]-2'-one (1229649-00-6) → 1-benzyl-3-(2-hydroxyethyl)-3-(hydroxymethyl)-2-oxo-2,3-dihydroindole (1229649-01-7)

Guidance literature:

1'-benzyl-5-hydroxy-2',3',4,5-tetrahydro-2H-spiro[furan-3,3'-indolin]-2'-one; With sodium tetrahydroborate; In methanol; at 20 ℃; for 1.5h;

With hydrogenchloride; water; In methanol;

DOI:10.1016/j.tet.2010.03.047

Reference yield: 85.0%

1-benzyl-3-(2-hydroxyethyl)-3-(hydroxymethyl)-2-oxo-2,3-dihydroindole (1229649-01-7) + methanesulfonyl chloride (124-63-0) → 2-(1-benzyl-3-((methylsulfonyloxy)methyl)-2-oxo-2,3-dihydroindol-3-yl)ethyl methanesulfonate (1229649-02-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tet.2010.03.047

upstream raw materials:

1'-benzyl-5-hydroxy-2',3',4,5-tetrahydro-2H-spiro[furan-3,3'-indolin]-2'-one

Downstream raw materials:

2-(1-benzyl-3-((methylsulfonyloxy)methyl)-2-oxo-2,3-dihydroindol-3-yl)ethyl methanesulfonate