Technology Process of 2-[(3,4-Dimethoxyphenyl)methyl]-4,5-dimethoxybenzaldehyde
There total 9 articles about 2-[(3,4-Dimethoxyphenyl)methyl]-4,5-dimethoxybenzaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
diethyl ether;
for 2h;
Ambient temperature;
DOI:10.1021/jo00368a018
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) n-BuLi / 1) THF, -78 deg C, 5 min, 2) THF, a) -78 deg C to room temperature, b) 17 h
2: 73 percent / trifluoroacetic acid, NaBH4 / acetic acid; CH2Cl2 / 0.1 h / 0 °C
3: 1) n-BuLi / 1) THF, -78 deg C, 1 min, 2) a) -78 deg C, 1 h, b) room temperature, 50 min
With
sodium tetrahydroborate; n-butyllithium; trifluoroacetic acid;
In
dichloromethane; acetic acid;
DOI:10.1021/jo00067a057
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / Br2, CH3COOH / 5 h / Ambient temperature
2: 98 percent / p-toluenosulfonic acid / benzene / 2 h / Heating
3: 1.) tetramethylene diamine, n-butyllithium, (n-Bu)3P*CuI / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, from -78 deg C to RT, 0.5 h
4: 95 percent / 10percent aq. HCl / diethyl ether / 2 h / Ambient temperature
With
hydrogenchloride; n-butyllithium; CuI*P(n-Bu)3; N,N,N,N,-tetramethylethylenediamine; bromine; toluene-4-sulfonic acid; acetic acid;
In
diethyl ether; benzene;
DOI:10.1021/jo00368a018
