Technology Process of 6-(3,4-dimethoxybenzyl)veratrldehyde ethylene glycol acetal
There total 4 articles about 6-(3,4-dimethoxybenzyl)veratrldehyde ethylene glycol acetal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 80 percent / Br2, CH3COOH / 5 h / Ambient temperature
2: 98 percent / p-toluenosulfonic acid / benzene / 2 h / Heating
3: 1.) tetramethylene diamine, n-butyllithium, (n-Bu)3P*CuI / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, from -78 deg C to RT, 0.5 h
With
n-butyllithium; CuI*P(n-Bu)3; N,N,N,N,-tetramethylethylenediamine; bromine; toluene-4-sulfonic acid; acetic acid;
In
benzene;
DOI:10.1021/jo00368a018
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 98 percent / p-toluenosulfonic acid / benzene / 2 h / Heating
2: 1.) tetramethylene diamine, n-butyllithium, (n-Bu)3P*CuI / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, from -78 deg C to RT, 0.5 h
With
n-butyllithium; CuI*P(n-Bu)3; N,N,N,N,-tetramethylethylenediamine; toluene-4-sulfonic acid;
In
benzene;
DOI:10.1021/jo00368a018
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 82 percent / PBr3 / CH2Cl2 / Ambient temperature
2: 1.) tetramethylene diamine, n-butyllithium, (n-Bu)3P*CuI / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, from -78 deg C to RT, 0.5 h
With
n-butyllithium; CuI*P(n-Bu)3; N,N,N,N,-tetramethylethylenediamine; phosphorus tribromide;
In
dichloromethane;
DOI:10.1021/jo00368a018
