(R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chromane

Base Information

Chemical Name:(R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chromane
CAS No.:906079-31-0
Molecular Formula:C₃₆H₅₀O₂
Molecular Weight:514.792
Hs Code.:

Synonyms:(R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chromane

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Chemical Property of (R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chromane

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Technology Process of (R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chromane

There total 20 articles about (R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chromane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 906079-30-9
(2S)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyl-2-(phenylsulfonyl)trideca-3,7,11-trien-1-yl)chromane

: 906079-31-0
(R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chromane

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium triethylborohydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 906079-28-5
(S)-[3,4-dihydro-6-benzyloxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl]methyl trifluoromethane-sulfonate

: 906079-31-0
(R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chromane

Guidance literature:: Multi-step reaction with 2 steps

1.1: hexamethylphosphoric triamide; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 60 percent / tetrahydrofuran; hexane / 18 h / -78 - 20 °C

2.1: 76 percent / lithium triethylborohydride / PdCl₂[1,3-bis(diphenylphosphino)propane] / tetrahydrofuran / 0 - 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; lithium triethylborohydride; bis(diphenylphosphino)propanepalladium(II) dichloride; In tetrahydrofuran; hexane;
DOI:10.1016/j.bmc.2006.03.035

Reference yield:

: 69371-87-5
(S)-(-)-6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-ylmethanol

: 906079-31-0
(R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chromane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 62 percent / triethylamine / CH₂Cl₂ / 0.5 h / -10 °C

2.1: hexamethylphosphoric triamide; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 60 percent / tetrahydrofuran; hexane / 18 h / -78 - 20 °C

3.1: 76 percent / lithium triethylborohydride / PdCl₂[1,3-bis(diphenylphosphino)propane] / tetrahydrofuran / 0 - 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; lithium triethylborohydride; triethylamine; bis(diphenylphosphino)propanepalladium(II) dichloride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.bmc.2006.03.035