Technology Process of 2-ethyl-3-fluoro-4-(methylsulfonyl)benzoic acid
There total 8 articles about 2-ethyl-3-fluoro-4-(methylsulfonyl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Oxone; sodium hydrogencarbonate; sodium hydroxide;
In
water; acetone;
at 0 ℃;
for 0.166667h;
DOI:10.1021/jm3007933
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triethylamine / dichloromethane / 5 h / 20 °C
2.1: lithium bromide / acetone / 3 h / Reflux
3.1: magnesium; ethylene dibromide / diethyl ether / 1.5 h / Reflux
4.1: iron; bromine / chloroform / 20 °C
5.1: isopropylmagnesium bromide / tetrahydrofuran / 24 h / 0 - 20 °C
5.2: 0.67 h / Cooling with ice
6.1: sodium hydroxide / dimethyl sulfoxide / 0.5 h / 20 °C
6.2: 4 h / 55 - 60 °C
7.1: sodium hydroxide; sodium hydrogencarbonate; Oxone / water; acetone / 0.17 h / 0 °C
With
Oxone; bromine; isopropylmagnesium bromide; iron; sodium hydrogencarbonate; magnesium; ethylene dibromide; triethylamine; lithium bromide; sodium hydroxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; chloroform; water; dimethyl sulfoxide; acetone;
DOI:10.1021/jm3007933
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: magnesium; ethylene dibromide / diethyl ether / 1.5 h / Reflux
2.1: iron; bromine / chloroform / 20 °C
3.1: isopropylmagnesium bromide / tetrahydrofuran / 24 h / 0 - 20 °C
3.2: 0.67 h / Cooling with ice
4.1: sodium hydroxide / dimethyl sulfoxide / 0.5 h / 20 °C
4.2: 4 h / 55 - 60 °C
5.1: sodium hydroxide; sodium hydrogencarbonate; Oxone / water; acetone / 0.17 h / 0 °C
With
Oxone; bromine; isopropylmagnesium bromide; iron; sodium hydrogencarbonate; magnesium; ethylene dibromide; sodium hydroxide;
In
tetrahydrofuran; diethyl ether; chloroform; water; dimethyl sulfoxide; acetone;
DOI:10.1021/jm3007933
