Methanesulfonic acid (5S,8aR)-3-oxo-hexahydro-oxazolo[3,4-a]pyridin-5-ylmethyl ester

Base Information

Chemical Name:Methanesulfonic acid (5S,8aR)-3-oxo-hexahydro-oxazolo[3,4-a]pyridin-5-ylmethyl ester
CAS No.:177341-39-8
Molecular Formula:C₉H₁₅NO₅S
Molecular Weight:249.288
Hs Code.:

Synonyms:Methanesulfonic acid (5S,8aR)-3-oxo-hexahydro-oxazolo[3,4-a]pyridin-5-ylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methanesulfonic acid (5S,8aR)-3-oxo-hexahydro-oxazolo[3,4-a]pyridin-5-ylmethyl ester

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Technology Process of Methanesulfonic acid (5S,8aR)-3-oxo-hexahydro-oxazolo[3,4-a]pyridin-5-ylmethyl ester

There total 1 articles about Methanesulfonic acid (5S,8aR)-3-oxo-hexahydro-oxazolo[3,4-a]pyridin-5-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 177341-38-7
(2R,6S)-2-Acetoxymethyl-6-methanesulfonyloxymethyl-piperidine-1-carboxylic acid benzyl ester

: (1R,5S)-3-Oxa-9-aza-bicyclo[3.3.1]nonane-9-carboxylic acid benzyl ester

: 177341-39-8
Methanesulfonic acid (5S,8aR)-3-oxo-hexahydro-oxazolo[3,4-a]pyridin-5-ylmethyl ester

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; for 1h;
DOI:10.1021/jo9519569

Reference yield:

: 177341-39-8
Methanesulfonic acid (5S,8aR)-3-oxo-hexahydro-oxazolo[3,4-a]pyridin-5-ylmethyl ester

: 177473-32-4
((2R,6R)-1-Benzyl-6-methyl-piperidin-2-yl)-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / NaBH₄ / dimethylsulfoxide / 8 h / 80 - 90 °C

2: 1.) KOH, 2.) diisopropylethylamine / 1.) methanol, reflux, 40 h, 2.) acetonitrile, reflux, 3 h

With potassium hydroxide; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide;
DOI:10.1021/jo9519569

Reference yield:

: 177341-39-8
Methanesulfonic acid (5S,8aR)-3-oxo-hexahydro-oxazolo[3,4-a]pyridin-5-ylmethyl ester

: 177473-33-5
(2R,6R)-1-Benzyl-6-methyl-piperidine-2-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / NaBH₄ / dimethylsulfoxide / 8 h / 80 - 90 °C

2: 1.) KOH, 2.) diisopropylethylamine / 1.) methanol, reflux, 40 h, 2.) acetonitrile, reflux, 3 h

3: oxalyl chloride, DMSO / CH₂Cl₂ / 1 h / -78 °C

With potassium hydroxide; sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo9519569