177341-38-7

Basic information

• Product Name: (2R,6S)-2-Acetoxymethyl-6-methanesulfonyloxymethyl-piperidine-1-carboxylic acid benzyl ester
• Synonyms: (2R,6S)-2-Acetoxymethyl-6-methanesulfonyloxymethyl-piperidine-1-carboxylic acid benzyl ester
• CAS NO: 177341-38-7
• Molecular Weight: 399.465
• Mol File: 177341-38-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,6S)-2-Acetoxymethyl-6-methanesulfonyloxymethyl-piperidine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,6S)-2-Acetoxymethyl-6-methanesulfonyloxymethyl-piperidine-1-carboxylic acid benzyl ester(177341-38-7)
• EPA Substance Registry System: (2R,6S)-2-Acetoxymethyl-6-methanesulfonyloxymethyl-piperidine-1-carboxylic acid benzyl ester(177341-38-7)

Safety Data

• Hazardous Substances Data: 177341-38-7(Hazardous Substances Data)

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 144433-72-7 N-benzyloxycarbonyl-cis-2(R)-(acetoxymethyl)-6(S)-(hydroxymethyl)piperidine 
• 59234-46-7 dimethyl (2R,6S)-piperidine-2,6-dicarboxylate 
• 499-83-2 Pyridine-2,6-dicarboxylic acid 
• 138-60-3 chelidamic acid 
• 501-53-1 benzyl chloroformate 
• 144433-70-5 N-carbobenzoxy-cis-2,6-bis(hydroxymethyl)piperidine 
• 144433-68-1 cis-(N-benzyloxycarbonyl)-2,6-di-carboxymethyl piperidine 
• 144433-71-6 N-benzyloxycarbonyl-cis-2,6-(acetoxymethyl)piperidine 

Downstream Products

• 177473-32-4 ((2R,6R)-1-Benzyl-6-methyl-piperidin-2-yl)-methanol 
• 177473-33-5 (2R,6R)-1-Benzyl-6-methyl-piperidine-2-carbaldehyde 
• 177341-39-8 Methanesulfonic acid (5S,8aR)-3-oxo-hexahydro-oxazolo[3,4-a]pyridin-5-ylmethyl ester 

Relevant articles and documents

Enzymatic route to chiral, nonracemic cis-2,6- and cis,cis-2,4,6-substituted piperidines. Synthesis of (+)-dihydropinidine and dendrobate alkaloid (+)-241D

Piperidine-based compounds are an important class of natural alkaloids found in plants, insects, and amphibians. A general asymmetric synthesis of 2-alkyl-6-methylpiperidines is presented via the enzymatic desymmetrization of meso cis-2,6- and cis,cis-2,4,6-substituted piperidines with Aspergillus niger lipase (ANL). The enzymatic reaction proceeds in excellent chemical yield and high enantiotopic selectivity (ee ≥ 98%). The general method is used to effect the synthesis of (±)-dihydropinidine-HCl as well as the first asymmetric synthesis of dendrobate alkaloid (+)-241D.