Technology Process of N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-4-(benzyloxy)pentanamide
There total 10 articles about N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-4-(benzyloxy)pentanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(benzyloxy)pentanoic acid;
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
N-[2-(6-amino-7-hydroxy-2,3-dihydro-1H-inden-1-yl)ethyl]acetamide hydrochloride;
With
pyridine;
In
dichloromethane;
at 0 - 20 ℃;
for 0.25h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: nitric acid; acetic anhydride / acetic acid / 3 h / 20 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 40 h / 20 °C
3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C
3.2: 0.5 h
4.1: hydrogen; triethylamine / palladium 10% on activated carbon / ethyl acetate / 1.5 h / 20 °C
5.1: ammonia; hydrogen / cobalt / ethanol / 2 h / 20 °C
6.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C
7.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C
8.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C
9.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 0 °C
9.2: 0.25 h / 0 - 20 °C
With
oxalyl dichloride; ammonia; hydrogen; nitric acid; acetic anhydride; boron tribromide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide;
palladium 10% on activated carbon; cobalt;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: ammonia; hydrogen / cobalt / ethanol / 2 h / 20 °C
2.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C
3.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C
4.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C
5.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 0 °C
5.2: 0.25 h / 0 - 20 °C
With
oxalyl dichloride; ammonia; hydrogen; boron tribromide; triethylamine; N,N-dimethyl-formamide;
palladium 10% on activated carbon; cobalt;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
![N-[2-(6-amino-7-hydroxy-2,3-dihydro-1H-inden-1-yl)ethyl]acetamide hydrochloride](/Databaselist/images/loading.webp)
