Flumequine

Base Information Edit

Chemical Name:Flumequine
CAS No.:42835-25-6
Deprecated CAS:143984-63-8
Molecular Formula:C14H12FNO3
Molecular Weight:261.253
Hs Code.:2933990090
European Community (EC) Number:255-962-6
NSC Number:757806
UNII:UVG8VSP2SJ
DSSTox Substance ID:DTXSID5045623
Nikkaji Number:J16.025C
Wikipedia:Flumequine
Wikidata:Q3074500
NCI Thesaurus Code:C80639
Metabolomics Workbench ID:49610
ChEMBL ID:CHEMBL370252
Mol file:42835-25-6.mol

Synonyms:Apurone;flumequine;R 802;R-802

Suppliers and Price of Flumequine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Flumequine
500ul
$ 360.00

Usbiological
Flumequine
500ul
$ 306.00

TRC
Flumequine
10mg
$ 50.00

TRC
Flumequine
50mg
$ 60.00

TCI Chemical
Flumequine >98.0%(HPLC)(T)
25g
$ 246.00

TCI Chemical
Flumequine >98.0%(HPLC)(T)
5g
$ 91.00

Sigma-Aldrich
Flumequine
1g
$ 46.30

Sigma-Aldrich
Flumequine VETRANAL
250mg
$ 55.90

Sigma-Aldrich
Flumequine
5g
$ 144.00

Sigma-Aldrich
Flumequine European Pharmacopoeia (EP) Reference Standard
$ 190.00

Total 154 raw suppliers

Chemical Property of Flumequine Edit

Chemical Property:

Appearance/Colour:white to off-white powder
Vapor Pressure:1.66E-08mmHg at 25°C
Melting Point:253- 255 °C
Refractive Index:1.645
Boiling Point:439.7 °C at 760 mmHg
PKA:pKa 6.42(H2O t=25.0 I=0.025)(Approximate)
Flash Point:219.7 °C
PSA：59.30000
Density:1.45 g/cm³
LogP:2.34600
Storage Temp.:0-6°C
Solubility.:1 M NH4OH: soluble50mg/mL
Water Solubility.:Soluble in DMSO and dilute alkali hydroxides. Insoluble in water
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:261.08012141
Heavy Atom Count:19
Complexity:462

Purity/Quality:

99% ^*data from raw suppliers

Flumequine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 22-24/25-36/37/39-27-26

MSDS Files:: Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2)F)C(=O)O
Description Flumequine is a synthetic antibiotic belonging to the second-generation quinolone group and is mainly active against Gram negative bacteria. It is currently the only non-humans shared broad-spectrum antimicrobial veterinary drug. It is taken as the substitute product of norfloxacin. It has a strong bactericidal activity with excellent efficacy in the treatment of animal bacterial diseases. Its main effect is to inhibit bacterial deoxy nucleic acid (DNA) gyrase, interfering with the deoxyribonucleic acid (DNA) synthesis, thereby causing failure of cell for further division, and thus playing the role of killing bacteria. It is used in bovine, ovine, chicken, rabbits, goats, horses and salmonidae, however the establishment of MRLs was only requested for non-lactating cattle, pigs, sheep, chicken and salmonidae.
Uses Flumequine is a fluoroquinolone compound with antimicrobial activity against Gram-negative organisms. It is used in the treatment of enteric infections in food animals and in the treatment of bacterial infections in farmed fish. Flumequine is replacing oxolinic acid in aquaculture because of its more appropriate pharmacokinetic profile and lower effective doses (Treves-Brown 2000). Flumequine also has limited use in humans for the treatment of urinary tract infections.
Therapeutic Function Antibacterial

Technology Process of Flumequine

There total 8 articles about Flumequine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.8%