42835-47-2

Usage

Uses

Flumequine Ethyl Ester is an impurity of Flumequine (F445000), a quinolone antibacterial.

Upstream product

• 105450-09-7 Diethyl (2-methyl-6-fluorotetrahydro-quinolin-1-yl)methylenemalonate 
• 42835-89-2 6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 42835-25-6 flumequine 
• 75-03-6 ethyl iodide 
• 1128-61-6 6-fluoro-2-methyl-quinoline 

Downstream Products

• 42835-73-4 9-Fluor-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzochinolizin-2-carbonsaeurehydrazid 
• 42835-25-6 flumequine 

Relevant academic research and scientific papers

Selective Catalytic Hydrogenation of Heteroarenes with N-Graphene-Modified Cobalt Nanoparticles (Co3O4-Co/NGratα-Al2O3)

Cobalt oxide/cobalt-based nanoparticles featuring a core-shell structure and nitrogen-doped graphene layers on alumina are obtained by pyrolysis of Co(OAc)2/phenanthroline. The resulting core-shell material (Co3O4-Co/NGratα-Al2O3) was successfully applied in the catalytic hydrogenation of a variety of N-heteroarenes including quinolines, acridines, benzo[h], and 1,5-naphthyridine as well as unprotected indoles. The peculiar structure of the novel heterogeneous catalyst enables activation of molecular hydrogen at comparably low temperature. Both high activity and selectivity were achieved in these hydrogenation processes, to give important building blocks for bioactive compounds as well as the pharmaceutical industry.

MACROLONE COMPOUNDS

A compound of formula (I) compositions comprising same, processes for their preparation and use of said compounds, particularly in the treatment of microbial infections.

MACROLONE COMPOUNDS

A compound of formula (I) compositions comprising same, processes for their preparation and use of said compounds, particularly in the treatment of microbial infections.

Synthesis, absolute configuration and intermediates of 9-fluoro- 6,7- dihydro-5-methyl-1-oxo-1H,5H-benzo[i.j]quinolizine-2-carboxylic acid (flumequine)

The antibacterial agent 9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H- benzo[i.j]quinolizine-2-carboxylic acid (flumequine) was synthesized in optically active form from 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ). Racemic FTHQ was resolved with the enantiomers of 3-bromocamphor-8- sulfonic acid. The configurations were established by X-ray structures of the two diastereoisomeric salts. Enantiomeric excesses were determined by 1H NMR analysis.