3'-de(oxyphosphinico)-3'-[methylene(methylimino)]-5'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridylyl-(3'->5')-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridine

Base Information

Chemical Name:3'-de(oxyphosphinico)-3'-[methylene(methylimino)]-5'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridylyl-(3'->5')-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridine
CAS No.:183737-13-5
Molecular Formula:C₅₆H₇₁N₅O₁₁Si₂
Molecular Weight:1046.38
Hs Code.:

3'-de(oxyphosphinico)-3'-[methylene(methylimino)]-5'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridylyl-(3'->5')-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridine

Synonyms:3'-de(oxyphosphinico)-3'-[methylene(methylimino)]-5'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridylyl-(3'->5')-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridine

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Chemical Property of 3'-de(oxyphosphinico)-3'-[methylene(methylimino)]-5'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridylyl-(3'->5')-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridine

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Technology Process of 3'-de(oxyphosphinico)-3'-[methylene(methylimino)]-5'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridylyl-(3'->5')-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridine

There total 5 articles about 3'-de(oxyphosphinico)-3'-[methylene(methylimino)]-5'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridylyl-(3'->5')-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 183737-45-3
3'-de(oxyphosphinico)-3'-(methyleneimino)-5'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridylyl-(3'->5')-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridine

: 183737-13-5
3'-de(oxyphosphinico)-3'-[methylene(methylimino)]-5'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridylyl-(3'->5')-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridine

Guidance literature:: With sodium cyanoborohydride; In acetic acid; for 1h; Ambient temperature;
DOI:10.1021/jo961549c

Reference yield:

: 1-[(2R,3R,4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 183737-13-5
3'-de(oxyphosphinico)-3'-[methylene(methylimino)]-5'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridylyl-(3'->5')-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) pyridine / 1) CH₂Cl₂, -10 deg C, 75 min; 2) CH₂Cl₂, pyridine, -10 deg C, 2.5 h

2: Bu₄NI / xylene / 0.5 h / 140 °C

3: 84 percent / bis(trimethylstannyl)benzopinacolate / benzene / 80 °C

4: 70 percent / NaBH₃CN / acetic acid / 1 h / Ambient temperature

With pyridine; tetra-(n-butyl)ammonium iodide; sodium cyanoborohydride; Bis-(trimethylzinn)-benzpinakolat; In acetic acid; xylene; benzene;
DOI:10.1021/jo961549c

Reference yield:

: 183737-27-1
1-[(2R,3S,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-iodo-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 183737-13-5
3'-de(oxyphosphinico)-3'-[methylene(methylimino)]-5'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridylyl-(3'->5')-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridine

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / bis(trimethylstannyl)benzopinacolate / benzene / 80 °C

2: 70 percent / NaBH₃CN / acetic acid / 1 h / Ambient temperature

With sodium cyanoborohydride; Bis-(trimethylzinn)-benzpinakolat; In acetic acid; benzene;
DOI:10.1021/jo961549c