(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) ((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone

Base Information

Chemical Name:(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) ((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone
CAS No.:1338706-20-9
Molecular Formula:C₃₀H₃₃ClN₂O₅
Molecular Weight:537.055
Hs Code.:

Synonyms:(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) ((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone

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Chemical Property of (2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) ((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone

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Technology Process of (2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) ((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone

There total 6 articles about (2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) ((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 2-chloro-3,4-bis[(4-methoxyphenyl)methoxy]benzoic acid

: 172739-03-6
(3aR,6aS)-2-methyl-octahydropyrrolo[3,4-c]pyrrole

: 1338706-20-9
(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) ((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone

Guidance literature:: 2-chloro-3,4-bis[(4-methoxyphenyl)methoxy]benzoic acid; With methanesulfonyl chloride; triethylamine; In N,N-dimethyl-formamide; at -10 ℃; for 0.5h; Inert atmosphere;

(3aR,6aS)-2-methyl-octahydropyrrolo[3,4-c]pyrrole; In N,N-dimethyl acetamide; N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.ejmech.2018.06.014

Reference yield: 52.0%

: 1338706-20-9
(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) ((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone

Guidance literature:: With triethylamine; In N,N-dimethyl acetamide; at -15 ℃; for 1.5h; Cooling with ice;

Reference yield:

: 52009-53-7
2-chloro-3,4-dimethoxy-benzoic acid

: 1338706-20-9
(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) ((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 3.5 h / 50 °C / Inert atmosphere

3.1: sodium hydroxide / tetrahydrofuran; methanol / 1.5 h / Reflux; Inert atmosphere

4.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl-formamide / 0.5 h / -10 °C / Inert atmosphere

4.2: 1 h / 0 °C / Inert atmosphere

With boron tribromide; potassium carbonate; methanesulfonyl chloride; triethylamine; sodium iodide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2018.06.014