N-(3-nitrophenyl)-4-(pyridin-3-yl)thiazol-2-amine hydrobromide

Base Information

• Chemical Name: N-(3-nitrophenyl)-4-(pyridin-3-yl)thiazol-2-amine hydrobromide
• CAS No.: 1143459-79-3
• Molecular Formula: BrH*C₁₄H₁₀N₄O₂S
• Molecular Weight: 379.237
• Mol file: 1143459-79-3.mol

Synonyms:N-(3-nitrophenyl)-4-(pyridin-3-yl)thiazol-2-amine hydrobromide

Chemical Property of N-(3-nitrophenyl)-4-(pyridin-3-yl)thiazol-2-amine hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N-(3-nitrophenyl)-4-(pyridin-3-yl)thiazol-2-amine hydrobromide

There total 1 articles about N-(3-nitrophenyl)-4-(pyridin-3-yl)thiazol-2-amine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-nitrophenylthiourea (709-72-8) + 3-(2-bromoacetyl)pyridine hydrobromide (17694-68-7) → N-(3-nitrophenyl)-4-(pyridin-3-yl)thiazol-2-amine hydrobromide (1143459-79-3)

Guidance literature:

In ethanol; for 2h; Reflux;

DOI:10.1021/jm800988r

Reference yield: 96.0%

N-(3-nitrophenyl)-4-(pyridin-3-yl)thiazol-2-amine hydrobromide (1143459-79-3) → N1-(4-(pyridin-3-yl)thiazol-2-yl)benzene-1,3-diamine (1143459-90-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; sodium carbonate; In tetrahydrofuran; at 50 ℃; for 12h; under 22801.5 Torr;

DOI:10.1021/jm800988r

upstream raw materials:

3-nitrophenylthiourea

3-(2-bromoacetyl)pyridine hydrobromide

Downstream raw materials:

N₁-(4-(pyridin-3-yl)thiazol-2-yl)benzene-1,3-diamine