(3S,4S)-tert-butyl 3-(tert-butyldiphenylsilyloxy)-4-(trifluoromethylsulfonamido)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(3S,4S)-tert-butyl 3-(tert-butyldiphenylsilyloxy)-4-(trifluoromethylsulfonamido)pyrrolidine-1-carboxylate
CAS No.:1333414-02-0
Molecular Formula:C₂₆H₃₅F₃N₂O₅SSi
Molecular Weight:572.721
Hs Code.:

Synonyms:(3S,4S)-tert-butyl 3-(tert-butyldiphenylsilyloxy)-4-(trifluoromethylsulfonamido)pyrrolidine-1-carboxylate

Suppliers and Price of (3S,4S)-tert-butyl 3-(tert-butyldiphenylsilyloxy)-4-(trifluoromethylsulfonamido)pyrrolidine-1-carboxylate

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Chemical Property of (3S,4S)-tert-butyl 3-(tert-butyldiphenylsilyloxy)-4-(trifluoromethylsulfonamido)pyrrolidine-1-carboxylate

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Technology Process of (3S,4S)-tert-butyl 3-(tert-butyldiphenylsilyloxy)-4-(trifluoromethylsulfonamido)pyrrolidine-1-carboxylate

There total 5 articles about (3S,4S)-tert-butyl 3-(tert-butyldiphenylsilyloxy)-4-(trifluoromethylsulfonamido)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1333413-99-2
(3S,4S)-tert-butyl 3-hydroxy-4-(trifluoromethylsulfonamido)pyrrolidine-1-carboxylate

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1333414-02-0
(3S,4S)-tert-butyl 3-(tert-butyldiphenylsilyloxy)-4-(trifluoromethylsulfonamido)pyrrolidine-1-carboxylate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 18h;
DOI:10.1002/chem.201101513

Reference yield:

: 164931-85-5
meso-N-trifluoroacetyl-3-pyrroline oxide

: 1333414-02-0
(3S,4S)-tert-butyl 3-(tert-butyldiphenylsilyloxy)-4-(trifluoromethylsulfonamido)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: trimethylsilylazide / diethyl ether

2: sodium carbonate

3: platinum(IV) oxide; hydrogen / methanol

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h

5: 1H-imidazole / N,N-dimethyl-formamide / 18 h

With 1H-imidazole; platinum(IV) oxide; trimethylsilylazide; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201101513

Reference yield:

: 183184-52-3
1-((3S,4S)-3-azido-4-hydroxypyrrolidin-1-yl)-2,2,2-trifluoroethan-1-one

: 1333414-02-0
(3S,4S)-tert-butyl 3-(tert-butyldiphenylsilyloxy)-4-(trifluoromethylsulfonamido)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate

2: platinum(IV) oxide; hydrogen / methanol

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h

4: 1H-imidazole / N,N-dimethyl-formamide / 18 h

With 1H-imidazole; platinum(IV) oxide; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201101513