benzyl (E)-(5S)-6-methyl-5-<(tert-butoxycarbonyl)amino>-4-oxo-2-heptenoate

Base Information

• Chemical Name: benzyl (E)-(5S)-6-methyl-5-<(tert-butoxycarbonyl)amino>-4-oxo-2-heptenoate
• CAS No.: 176504-92-0
• Molecular Formula: C₂₀H₂₇NO₅
• Molecular Weight: 361.438

Synonyms:benzyl (E)-(5S)-6-methyl-5-<(tert-butoxycarbonyl)amino>-4-oxo-2-heptenoate

Chemical Property of benzyl (E)-(5S)-6-methyl-5-<(tert-butoxycarbonyl)amino>-4-oxo-2-heptenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (E)-(5S)-6-methyl-5-<(tert-butoxycarbonyl)amino>-4-oxo-2-heptenoate

There total 2 articles about benzyl (E)-(5S)-6-methyl-5-<(tert-butoxycarbonyl)amino>-4-oxo-2-heptenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

benzylglyoxylate (52709-42-9) + (S)-1-(dimethoxyphosphoryl)-4-methyl-3-(t-butoxycarbonylamino)-pentan-2-one (129301-63-9) → benzyl (E)-(5S)-6-methyl-5-<(tert-butoxycarbonyl)amino>-4-oxo-2-heptenoate (176504-92-0)

Guidance literature:

With triethylamine; In acetonitrile; for 1h; Ambient temperature;

DOI:10.1021/jo951988w

Reference yield:

N-tert-butoxycarbonyl-L-valine methyl ester (58561-04-9) → benzyl (E)-(5S)-6-methyl-5-<(tert-butoxycarbonyl)amino>-4-oxo-2-heptenoate (176504-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 20 min, 2.) -78 deg C, 1 h; room temperature, 15 min

2: 72 percent / Et₃N / acetonitrile / 1 h / Ambient temperature

With n-butyllithium; triethylamine; In acetonitrile;

DOI:10.1021/jo951988w

Reference yield: 91.0%

tert-butyl allyl malonate (134209-82-8) + benzyl (E)-(5S)-6-methyl-5-<(tert-butoxycarbonyl)amino>-4-oxo-2-heptenoate (176504-92-0) → 2-Allyloxycarbonyl-3-((S)-3-tert-butoxycarbonylamino-4-methyl-2-oxo-pentyl)-succinic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:

With sodium hydride; In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1021/jo951988w

upstream raw materials:

benzylglyoxylate

(S)-1-(dimethoxyphosphoryl)-4-methyl-3-(t-butoxycarbonylamino)-pentan-2-one

N-tert-butoxycarbonyl-L-valine methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 176504-92-0 benzyl (E)-(5S)-6-methyl-5-<(tert-butoxycarbonyl)amino>-4-oxo-2-heptenoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send