Technology Process of 1-(2-(benzyloxy)-5-(2-fluoro-4-methylbenzoyl)phenyl)ethanone
There total 8 articles about 1-(2-(benzyloxy)-5-(2-fluoro-4-methylbenzoyl)phenyl)ethanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C16H13FO3;
With
sodium hydroxide;
In
DMF (N,N-dimethyl-formamide); water;
for 0.166667h;
benzyl bromide;
In
DMF (N,N-dimethyl-formamide); water;
for 2h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / 2 h / 180 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h
2.2: 2 h
With
aluminum (III) chloride; sodium hydride;
In
N,N-dimethyl-formamide;
1.1: |Fries Phenol Ester Rearrangement;
DOI:10.1002/bkcs.11049
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h
2.1: lithium hydroxide / tetrahydrofuran; water / 4 h / Reflux
3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 3 h / 20 °C
4.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere
4.2: 2.5 h / -78 - 20 °C / Inert atmosphere
5.1: hydrogenchloride / ethanol / 2 h / 20 °C
6.1: triethylamine / dichloromethane / 1 h
7.1: aluminum (III) chloride / 2 h / 180 °C
8.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h
8.2: 2 h
With
hydrogenchloride; aluminum (III) chloride; n-butyllithium; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
7.1: |Fries Phenol Ester Rearrangement;
DOI:10.1002/bkcs.11049
